CAS 2353492-68-7

1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

Description:

1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- is a complex organic compound characterized by its multi-ring structure and various functional groups, including amines, piperidines, and a phosphinyl moiety. This compound is likely to exhibit significant biological activity due to its intricate arrangement of substituents, which may interact with biological targets such as enzymes or receptors. The presence of chlorine and methoxy groups suggests potential lipophilicity, which can influence its pharmacokinetic properties. Additionally, the isoindole core may contribute to its stability and reactivity. As a synthetic compound, it may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific diseases. Its CAS number, 2353492-68-7, allows for precise identification and retrieval of information regarding its properties, synthesis, and applications in scientific literature.

Formula: C₄₃H₄₈ClN₁₀O₇P

Synonyms:

• SIAIS164018
• 1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

SIAIS164018

CAS: 2353492-68-7

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

Formula: C₄₃H₄₈ClN₁₀O₇P

Color and Shape: Solid

Molecular weight: 883.33

Ref: TM-T74570