CAS 23599-69-1

(+)-Norisoboldine

Description:

(+)-Norisoboldine is an alkaloid derived from the plant species of the Amaryllidaceae family, particularly known for its presence in various medicinal plants. It is characterized by its complex bicyclic structure, which includes a phenolic moiety and a nitrogen-containing heterocycle. This compound exhibits a range of biological activities, including potential anti-inflammatory and neuroprotective effects, making it of interest in pharmacological research. The stereochemistry of (+)-Norisoboldine is significant, as its specific optical rotation indicates its chiral nature, which can influence its biological interactions. Additionally, it is soluble in organic solvents, which facilitates its extraction and purification from plant sources. The compound's molecular formula reflects its composition of carbon, hydrogen, nitrogen, and oxygen, contributing to its diverse chemical properties. Research into (+)-Norisoboldine continues to explore its potential therapeutic applications, particularly in the context of neurodegenerative diseases and other health conditions.

Formula: C₁₈H₁₉NO₄

InChI: InChI=1/C18H19NO4/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1

InChI key: InChIKey=HORZNQYQXBFWNZ-LBPRGKRZSA-N

SMILES: OC1=C2C=3[C@](CC=4C2=CC(OC)=C(O)C4)(NCCC3C=C1OC)[H]

Synonyms:

• (+)-Laurelliptine
• (+)-N-Norisoboldine
• (6aS)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
• (6aS)-2,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol
• (6aS)-5,6,6a,7-Tetrahydro-2,10-dimethoxy-4H-dibenzo[de,g]quinoline-1,9-diol
• (S)-(+)-Laurelliptine
• 4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (S)-
• 4H-dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (6aS)-
• 6aα-Noraporphine-1,9-diol, 2,10-dimethoxy-
• Norisoboldine, 98%, from Lindera aggregata (Sims) Kosterm.
• (+)-Norisoboldine

4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (6aS)-

CAS: 23599-69-1

Formula: C₁₈H₁₉NO₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 313.3478

Ref: IN-DA002NU2

(S)-2,10-Dimethoxy-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1,9-Diol

CAS: 23599-69-1

(S)-2,10-Dimethoxy-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1,9-Diol

Purity: 98%

Molecular weight: 313.35g/mol

Ref: 54-OR1023235

Norisoboldine

CAS: 23599-69-1

Formula: C₁₈H₁₉NO₄

Molecular weight: 313.35

Ref: 7W-GY9533

Norisoboldine

CAS: 23599-69-1

Norisoboldine is the main isoquinoline alkaloid occurring in Radix Linderae, the dry roots of Lindera aggregata (Lauraceae family)，it has been previously implicated to be able to ameliorate the synovial inflammation and abnormal immune conditions in collagen-induced arthritis of mice; it inhibits the macrophage activation and the resultant production of pro-inflammatory cytokines via down-regulating the activation of MAPKs signaling pathways rather than NF-κB.

Formula: C₁₈H₁₉NO₄

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 313.353

Ref: BP-BP1007

Norisoboldine

CAS: 23599-69-1

Formula: C₁₈H₁₉NO₄

Molecular weight: 313.35

Ref: 4Z-M-190003

Norisoboldine

CAS: 23599-69-1

Norisoboldine, potential rheumatoid arthritis therapy, protects joints and modulates immunity by inhibiting MAPKs, not NF-κB.

Formula: C₁₈H₁₉NO₄

Purity: 98.12% - 99.7%

Color and Shape: Solid

Molecular weight: 313.35

Ref: TM-T5S1895

Norisoboldine

CAS: 23599-69-1

Natural alkaloid

Formula: C₁₈H₁₉NO₄

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 313.35

Ref: 5G-83266

4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (6aS)-

CAS: 23599-69-1

Purity: 99%

Molecular weight: 313.3529968

Ref: 10-F865876

Norisoboldine

CAS: 23599-69-1

Norisoboldine is a drug that inhibits the activity of P-glycoprotein (P-gp) and has significant cytotoxicity. Norisoboldine has been shown to have therapeutic potential for the treatment of bowel disease, including ulcerative colitis and Crohn's Disease. This drug also inhibits the production of proinflammatory cytokines such as IL-10, which may play a role in its therapeutic effects. Norisoboldine has been shown to inhibit mitochondrial membrane potential and to be an anti-inflammatory agent. It also has a high bioavailability in vivo, which may be due to its ability to bind tightly to human serum proteins.

Formula: C₁₈H₁₉NO₄

Purity: Min. 95%

Molecular weight: 313.35 g/mol

Ref: 3D-FN73860