CAS 23651-95-8

Droxidopa

Description:

Droxidopa, with the CAS number 23651-95-8, is a synthetic amino acid analog of norepinephrine, primarily used as a medication to treat neurogenic orthostatic hypotension. It functions as a prodrug, converting to norepinephrine in the body, which helps to increase blood pressure and improve blood flow. The chemical formula of droxidopa is C9H11NO4, and it has a molecular weight of approximately 197.19 g/mol. This compound is characterized by its ability to cross the blood-brain barrier, making it effective in treating conditions associated with low blood pressure due to autonomic dysfunction. Droxidopa is typically administered orally and is known for its relatively favorable safety profile, although it may cause side effects such as headache, nausea, and hypertension. Its pharmacokinetics involve rapid absorption and metabolism, with peak plasma concentrations occurring within a few hours post-administration. Overall, droxidopa represents a significant therapeutic option for patients suffering from specific forms of orthostatic hypotension.

Formula: C₉H₁₁NO₅

InChI: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

InChI key: InChIKey=QXWYKJLNLSIPIN-JGVFFNPUSA-N

SMILES: [C@@H]([C@@H](C(O)=O)N)(O)C1=CC(O)=C(O)C=C1

Synonyms:

• (-)-threo-3,4-Dihydroxyphenylserine
• (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid
• (2S,3S)-2-ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
• (betaS)-beta,3-dihydroxy-D-tyrosine
• (βR)-β,3-Dihydroxy-<span class="text-smallcaps">L</span>-tyrosine
• <span class="text-smallcaps">L</span>-DOPS
• <span class="text-smallcaps">L</span>-Threodops
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, (βR)-
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, threo-
• <span class="text-smallcaps">L</span>-threo-3,4-Dihydroxyphenylserine
• <span class="text-smallcaps">L</span>-threo-3-(3,4-Dihydroxyphenyl)serine
• <span class="text-smallcaps">L</span>-threo-DOPS
• <span class="text-smallcaps">L</span>-threo-β-(3,4-Dihydroxyphenyl)serine
• Northera
• Serine, 3-(3,4-dihydroxyphenyl)-
• Serine, 3-(3,4-dihydroxyphenyl)-, <span class="text-smallcaps">L</span>-threo-
• Sm 5688
• Tyrosine, Beta,3-Dihydroxy-
• beta,3-Dihydroxytyrosine
• threo-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid
• threo-3-(3,4-Dihydroxyphenyl)-<span class="text-smallcaps">L</span>-serine
• threo-Dopaserine
• Serine, 3-(3,4-dihydroxyphenyl)-, L-threo-
• L-Tyrosine, β,3-dihydroxy-, (βR)-
• (βR)-β,3-Dihydroxy-L-tyrosine
• L-threo-3,4-Dihydroxyphenylserine

Droxidopa

CAS: 23651-95-8

Formula: C₉H₁₁NO₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 213.19

Ref: 3B-D4235

Droxidopa

CAS: 23651-95-8

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Formula: C₉H₁₁NO₅

Color and Shape: White Pale Yellow Powder

Molecular weight: 213.06372

Ref: 45-1229600

L-Tyrosine, β,3-dihydroxy-, (βR)-

CAS: 23651-95-8

Formula: C₉H₁₁NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.1873

Ref: IN-DA002O25

Droxidopa

CAS: 23651-95-8

Formula: C₉H₁₁NO₅

Color and Shape: Off-White Solid

Molecular weight: 213.19

Ref: 4Z-D-155003

Droxidopa (L-threo-3-(3,4-Dihydroxyphenyl)serine)

CAS: 23651-95-8

Formula: C₉H₁₁NO₅

Molecular weight: 213.19

Ref: 7W-GP7171

Droxidopa

CAS: 23651-95-8

Color and Shape: Neat

Ref: 86-MM3786.00

Droxidopa

CAS: 23651-95-8

Droxidopa (L-DOPS), an oral prodrug, treats symptomatic orthostatic hypotension from neurogenic autonomic failure.

Formula: C₉H₁₁NO₅

Purity: 97.27% - 99.88%

Color and Shape: Solid

Molecular weight: 213.19

Ref: TM-T2547

L-threo-Droxidopa

Controlled Product

CAS: 23651-95-8

Formula: C₉H₁₁NO₅

Color and Shape: Neat

Molecular weight: 213.19

Ref: TR-D689960

Droxidopa

CAS: 23651-95-8

Purity: 98%

Molecular weight: 213.1889954

Ref: 10-F787591

L-threo-Droxidopa-13C6

Controlled Product

CAS: 23651-95-8

Formula: C₃C₆H₁₁NO₅

Color and Shape: Neat

Molecular weight: 216.119

Ref: TR-D689963

L-threo-droxidopa

CAS: 23651-95-8

L-threo-droxidopa is a prodrug that is hydrolyzed in the liver to L-3,4-dihydroxyphenylalanine (L-DOPA) and then metabolized by dopamine β-hydroxylase to form dopamine. This drug has been shown to be effective for the treatment of Parkinson's disease. The long-term efficacy of this drug is unknown, but it has been shown to be safe and well tolerated for up to six months. L-threo-droxidopa has also been shown to be effective in lowering systolic blood pressure in patients with mild hypertension. The side effects of this drug include symptoms such as nausea, vomiting, dizziness, headache, and insomnia. However, these side effects are often transient and do not require discontinuation of treatment with this medication. There are no known interactions between L-threo-droxidopa and other drugs or foods. Pharmacological

Formula: C₉H₁₁NO₅

Purity: Min. 95%

Color and Shape: Off-White To Light (Or Pale) Beige Solid

Molecular weight: 213.19 g/mol

Ref: 3D-FT28252