CAS 23668-11-3

Pactamycin

Description:

Pactamycin is a complex natural product classified as an antibiotic, originally derived from the bacterium *Streptomyces pactum*. It is known for its unique structure, which includes a polycyclic core and various functional groups that contribute to its biological activity. Pactamycin exhibits potent antibacterial properties, particularly against Gram-positive bacteria, and has been studied for its potential use in cancer therapy due to its ability to inhibit protein synthesis. The mechanism of action involves interference with the ribosomal function, leading to the disruption of protein production in susceptible organisms. Additionally, pactamycin has shown activity against certain viruses and fungi, making it a compound of interest in the field of medicinal chemistry. However, its clinical use has been limited due to toxicity concerns and the development of resistance. Research continues to explore its derivatives and analogs to enhance efficacy and reduce side effects. Overall, pactamycin represents a significant example of the diverse capabilities of natural products in drug discovery and development.

Formula: C₂₈H₃₈N₄O₈

InChI: InChI=1S/C28H38N4O8/c1-15-9-7-12-20(35)21(15)24(36)40-14-27(39)23(30-19-11-8-10-18(13-19)16(2)33)22(29)28(17(3)34,26(27,4)38)31-25(37)32(5)6/h7-13,17,22-23,30,34-35,38-39H,14,29H2,1-6H3,(H,31,37)/t17-,22-,23-,26-,27+,28-/m0/s1

InChI key: InChIKey=WVIUOSJLUCTGFK-JUJPXXQGSA-N

SMILES: N(C(N(C)C)=O)[C@]1([C@H](C)O)[C@@](C)(O)[C@](COC(=O)C2=C(C)C=CC=C2O)(O)[C@@H](NC3=CC(C(C)=O)=CC=C3)[C@@H]1N

Synonyms:

• 23668-11-3
• 2,6-Cresotic acid, monoester with 3-[4-(m-acetylanilino)-5-amino-2,3-dihydroxy-1-(1-hydroxyethyl)-2-(hydroxymethyl)-3-methylcyclopentyl]-1,1-dimethylurea
• NSC 52947
• {(1S,2R,3R,4S,5S)-5-[(3-Acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate
• Benzoic acid, 2-hydroxy-6-methyl-, [5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl]methyl ester, [1S-[1α,2β,3α,3(R*),4α,5β]]-
• Pactamycin
• Benzoic acid, 2-hydroxy-6-methyl-, [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester

Pactamycin

CAS: 23668-11-3

Pactamycin, an antibiotic from Streptomyces pactum, serves as an antineoplastic and protein synthesis inhibitor.

Formula: C₂₈H₃₈N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 558.632

Ref: TM-T25914

Pactamycin

CAS: 23668-11-3

Pactamycin is an antibiotic, which is a natural product derived from the soil bacterium Streptomyces pactum. It operates by inhibiting protein synthesis through the interference with the initiation phase. Specifically, it disrupts the binding of initiator tRNA to the small ribosomal subunit, which is crucial for the initiation of translation, thereby halting cellular protein production.

Formula: C₂₈H₃₈N₄O₈

Purity: Min. 95%

Molecular weight: 558.6 g/mol

Ref: 3D-YAA66811

Pactamycin

CAS: 23668-11-3

Formula: C₂₈H₃₈N₄O₈

Molecular weight: 558.63

Ref: 4Z-P-387001