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CAS 23668-11-3

:

Pactamycin

Description:
Pactamycin is a complex natural product classified as an antibiotic, originally derived from the bacterium *Streptomyces pactum*. It is known for its unique structure, which includes a polycyclic core and various functional groups that contribute to its biological activity. Pactamycin exhibits potent antibacterial properties, particularly against Gram-positive bacteria, and has been studied for its potential use in cancer therapy due to its ability to inhibit protein synthesis. The mechanism of action involves interference with the ribosomal function, leading to the disruption of protein production in susceptible organisms. Additionally, pactamycin has shown activity against certain viruses and fungi, making it a compound of interest in the field of medicinal chemistry. However, its clinical use has been limited due to toxicity concerns and the development of resistance. Research continues to explore its derivatives and analogs to enhance efficacy and reduce side effects. Overall, pactamycin represents a significant example of the diverse capabilities of natural products in drug discovery and development.
Formula:C28H38N4O8
InChI:InChI=1S/C28H38N4O8/c1-15-9-7-12-20(35)21(15)24(36)40-14-27(39)23(30-19-11-8-10-18(13-19)16(2)33)22(29)28(17(3)34,26(27,4)38)31-25(37)32(5)6/h7-13,17,22-23,30,34-35,38-39H,14,29H2,1-6H3,(H,31,37)/t17-,22-,23-,26-,27+,28-/m0/s1
InChI key:InChIKey=WVIUOSJLUCTGFK-JUJPXXQGSA-N
SMILES:N(C(N(C)C)=O)[C@]1([C@H](C)O)[C@@](C)(O)[C@](COC(=O)C2=C(C)C=CC=C2O)(O)[C@@H](NC3=CC(C(C)=O)=CC=C3)[C@@H]1N
Synonyms:
  • 23668-11-3
  • 2,6-Cresotic acid, monoester with 3-[4-(m-acetylanilino)-5-amino-2,3-dihydroxy-1-(1-hydroxyethyl)-2-(hydroxymethyl)-3-methylcyclopentyl]-1,1-dimethylurea
  • NSC 52947
  • {(1S,2R,3R,4S,5S)-5-[(3-Acetylphenyl)amino]-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl}methyl 2-hydroxy-6-methylbenzoate
  • Benzoic acid, 2-hydroxy-6-methyl-, [5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl]methyl ester, [1S-[1α,2β,3α,3(R*),4α,5β]]-
  • Pactamycin
  • Benzoic acid, 2-hydroxy-6-methyl-, [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester
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Found 3 products.