CAS 23669-79-6

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

Description:

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine, with the CAS number 23669-79-6, is a synthetic nucleoside derivative that features a deoxyuridine backbone modified with a bis(4-methoxyphenyl)phenylmethyl group at the 5′ position. This compound exhibits characteristics typical of nucleosides, including the ability to participate in hydrogen bonding due to the presence of the uracil base, which can influence its interactions with nucleic acids. The methoxyphenyl substituents enhance its lipophilicity and may improve its cellular uptake compared to unmodified nucleosides. Additionally, the presence of the bulky substituents can affect the compound's conformation and stability, potentially influencing its biological activity. Such modifications are often explored for their potential in therapeutic applications, including antiviral and anticancer strategies, as they can alter the pharmacokinetics and bioavailability of nucleoside analogs. Overall, this compound represents a class of modified nucleosides that are of interest in medicinal chemistry and drug development.

Formula: C₃₀H₃₀N₂O₇

InChI: InChI=1S/C30H30N2O7/c1-36-23-12-8-21(9-13-23)30(20-6-4-3-5-7-20,22-10-14-24(37-2)15-11-22)38-19-26-25(33)18-28(39-26)32-17-16-27(34)31-29(32)35/h3-17,25-26,28,33H,18-19H2,1-2H3,(H,31,34,35)/t25-,26+,28+/m0/s1

InChI key: InChIKey=BYGKUWPLEGHFKX-ZRRKCSAHSA-N

SMILES: C(OC[C@H]1O[C@H](C[C@@H]1O)N2C(=O)NC(=O)C=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• 1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxypentofuranosyl}pyrimidine-2,4(1H,3H)-dione
• 5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyuridine
• 5'-O-[Bis(4-Methoxyphenyl)Benzyl]-2'-Deoxyuridine
• 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxyuridine
• 5′-O-(Dimethoxytrityl)-2′-deoxyuridine
• 5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-
• Uridine, 5′-O-[α,α-bis(p-methoxyphenyl)benzyl]-2′-deoxy-

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine, 98%

CAS: 23669-79-6

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The

Formula: C₃₀H₃₀N₂O₇

Purity: 98%

Molecular weight: 530.57

Ref: 02-J65960

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

CAS: 23669-79-6

Formula: C₃₀H₃₀N₂O₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 530.5684

Ref: IN-DA002O38

2''-Deoxy-5''-O-DMT-uridine

CAS: 23669-79-6

Formula: C₃₀H₃₀N₂O₇

Molecular weight: 530.57

Ref: 7W-GN6427

5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyuridine

CAS: 23669-79-6

5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyuridine

Purity: 97%

Molecular weight: 530.57g/mol

Ref: 54-OR1030806

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

CAS: 23669-79-6

5'-O-DMT-dU, a dUTPase inhibitor (Ki > 1 mM) for E. coli, is used in DNA synthesis.

Formula: C₃₀H₃₀N₂O₇

Color and Shape: Solid

Molecular weight: 530.57

Ref: TM-T39912

2'-Deoxy-5'-O-DMT-uridine

CAS: 23669-79-6

2'-Deoxy-5'-O-DMT-uridine is a bifunctional drug that has both antibacterial and anticancer activity. This drug is used to treat leishmania infections, which are caused by protozoan parasites. 2'-Deoxy-5'-O-DMT-uridine suppresses the growth of these organisms by inhibiting RNA synthesis and protein synthesis. It also inhibits proliferation of cancer cells in vivo by targeting cancer cells with high levels of primary amines. 2'-Deoxy-5'-O-DMT-uridine is an effective chemotherapeutic agent that can be used to treat pancreatic cancers with high rates of primary amines (e.g., insulinoma).

Formula: C₃₀H₃₀N₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 530.58 g/mol

Ref: 3D-ND05965

5′-O-(4,4′-DIMETHOXYTRITYL)-2′-DEOXYURIDINE

CAS: 23669-79-6

Purity: 97%

Molecular weight: 530.5770264

Ref: 10-F792866