CAS 23680-84-4

4-Amino-2-chloro-6,7-dimethoxyquinazoline

Description:

4-Amino-2-chloro-6,7-dimethoxyquinazoline is a chemical compound characterized by its quinazoline core structure, which is a bicyclic compound containing a benzene ring fused to a pyrimidine ring. This particular compound features an amino group (-NH2) and a chloro group (-Cl) at specific positions on the quinazoline ring, along with two methoxy groups (-OCH3) at the 6 and 7 positions. These functional groups contribute to its chemical reactivity and potential biological activity. The presence of the amino group may enhance its solubility in polar solvents, while the chloro and methoxy groups can influence its pharmacological properties. This compound is of interest in medicinal chemistry, particularly for its potential applications in drug development, as quinazoline derivatives are known for various biological activities, including anti-cancer and anti-inflammatory effects. Its molecular structure and substituents can significantly affect its interaction with biological targets, making it a subject of research in the field of pharmaceuticals.

Formula: C₁₀H₁₀ClN₃O₂

InChI: InChI=1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)

InChI key: InChIKey=HWIIAAVGRHKSOJ-UHFFFAOYSA-N

SMILES: NC=1C2=C(C=C(OC)C(OC)=C2)N=C(Cl)N1

Synonyms:

• 2-Chloro-4-Amino-6,7-Dimethoxy Quinazoline
• 2-Chloro-4-Amino-6,7-Dimethoxyquinazoline
• 2-Chloro-6,7-Dimethoxy
• 2-Chloro-6,7-Dimethoxy-4-Aminoquinazoline
• 2-Chloro-6,7-Dimethoxy-Quinazolin-4-Amine
• 2-Chloro-6,7-dimethoxy-4-quinazolinamine
• 2-Chloro-6,7-dimethoxy-quinazolin-4-ylamine
• 2-Chloro-6,7-dimethoxyquinazolin-4-amine
• 2-chloro-4-Amino-6,7-Dimethoxy Quinazoiline
• 4-Amino-2-Chloro-6,7-Dimethoxy Quinazoline
• 4-Amino-2-Chloro-6,7-Dimethoxy-Quinzoline
• 4-Amino-2-Chloro-6,7-Dimethoxyquinazoline
• 4-Amino-2-Chloro-6,7-Dimethoxyquinozoline
• 4-Quinazolinamine, 2-chloro-6,7-dimethoxy-
• Quinazolinamine
• Quinazoline, 4-amino-2-chloro-6,7-dimethoxy-

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 239.66

Ref: 3B-A2151

PRAZOSIN IMPURITY A CRS

CAS: 23680-84-4

PRAZOSIN IMPURITY A CRS

Ref: 41-Y0002095

DOXAZOSIN IMPURITY F CRS

CAS: 23680-84-4

DOXAZOSIN IMPURITY F CRS

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: Powder

Molecular weight: 239.6583

Ref: 41-Y0000552

Doxazosin Related Compound C (2-chloro-4-amino-6,7-dimethoxyquinazoline)

CAS: 23680-84-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: White Powder

Molecular weight: 239.04615

Ref: 45-1225452

4-Quinazolinamine, 2-chloro-6,7-dimethoxy-

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 239.6583

Ref: IN-DA002O5G

Terazosin EP Impurity A (Alfuzosin EP Impurity B, Prazosin EP Impurity A)

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 239.66

Ref: 4Z-T-7516

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

4-Amino-2-chloro-6,7-dimethoxyquinazoline

Formula: C₁₀H₁₀ClN₃O₂

Purity: ≥95%

Color and Shape: solid

Molecular weight: 239.66g/mol

Ref: 54-OR10316

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Molecular weight: 239.66

Ref: 7W-GK0734

2-Chloro-6,7-dimethoxyquinazolin-4-amine

Controlled Product

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: Neat

Molecular weight: 239.66

Ref: 86-MM0386.01

2-Chloro-6,7-dimethoxyquinazolin-4-amine

Controlled Product

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: Neat

Molecular weight: 239.66

Ref: 86-MM0085.04

Prazosin EP Impurity A

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Molecular weight: 239.66

Ref: ST-EA-CP-P28001

Doxazosin EP Impurity F

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Molecular weight: 239.66

Ref: ST-EA-CP-D26006

Alfuzosin EP Impurity B

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Molecular weight: 239.66

Ref: ST-EA-CP-A71002

Terazosin EP Impurity A

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Molecular weight: 239.66

Ref: ST-EA-CP-T17001

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

4-Amino-2-chloro-6,7-dimethoxyquinazoline (4ACDMQ) is a synthetic compound that has been used as a chemical intermediate. The chemical structure of 4ACDMQ is similar to that of the natural amino acid tryptophan. It is synthesized by reacting phosphorus pentachloride with 2,6,7-trimethoxyquinazoline in the presence of hydroxide solution and hexamethylphosphoramide. 4ACDMQ has been shown to be an inhibitor of ubiquitin proteasome system and has been used in functional studies on this system. The reaction yield for 4ACDMQ can be increased by using sodium hydroxide solution or n-dimethyl formamide as a solvent. Functional assays have shown binding properties for 4ACDMQ to proteins such as ubiquitin and proteasome subunits.

Formula: C₁₀H₁₀ClN₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 239.66 g/mol

Ref: 3D-FA156914

4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

Formula: C₁₀H₁₀ClN₃O₂

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 239.66

Ref: 10-F024926

4-Amino-2-chloro-6,7-dimethoxyquinazoline

Controlled Product

CAS: 23680-84-4

Impurity Terazosin EP Impurity A/ Doxazosin EP Impurity F /Alfuzosin EP Impurity B
Applications 4-Amino-2-chloro-6,7-dimethoxyquinazoline (Terazosin EP Impurity A) is an intermediate in the production on Terazosin. Alfuzosin EP Impurity B
References Shaw, Y., et al.: J. Med. Chem., 47, 4453 (2004), Mendes da Silva, J., et al.: Bioorg. Med. Chem., 16, 7254 (2008),

Formula: C₁₀H₁₀ClN₃O₂

Color and Shape: Neat

Molecular weight: 239.66

Ref: TR-A603439