CAS 2374782-02-0

FAPI-4

Description:

FAPI-4, or Fibroblast Activation Protein Inhibitor 4, is a small molecule that has garnered attention in the field of medicinal chemistry, particularly for its potential applications in cancer imaging and therapy. It is designed to selectively bind to fibroblast activation protein (FAP), which is overexpressed in various tumors and associated with the tumor microenvironment. The compound is characterized by its ability to inhibit FAP activity, thereby potentially disrupting tumor growth and metastasis. FAPI-4 is often utilized in radiolabeling for positron emission tomography (PET) imaging, allowing for the visualization of tumors in vivo. Its structure typically includes a core scaffold that facilitates binding to the target protein, along with functional groups that enhance its pharmacokinetic properties. The specificity and efficacy of FAPI-4 make it a promising candidate for further research in targeted cancer therapies and diagnostic imaging, contributing to the growing field of precision medicine.

Formula: C₄₀H₅₄F₂N₁₀O₁₀

Synonyms:

• FAPI
• FAPI-4
• FAPI04
• (S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
• 187366
• (S)-2,2’,2’’-[10-[2-[4-[3-[[4-[[2-(2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]carbamoyl]-6-quinolyl]oxy]propyl]-1-piperazinyl]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetic Acid

(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

CAS: 2374782-02-0

Formula: C₄₀H₅₄F₂N₁₀O₁₀

Purity: 98%

Molecular weight: 872.9146

Ref: IN-DA01NC8G

(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic a

CAS: 2374782-02-0

(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic a

Purity: 98%

Molecular weight: 872.93g/mol

Ref: 54-PC1007950

FAPI-4

CAS: 2374782-02-0

FAPI-4 is a FAP) inhibitor, a FAPI ligand that shows strong hepatic uptake in PET imaging of the primary liver cancer hepatocellular carcinoma (HCC).

Formula: C₄₀H₅₄F₂N₁₀O₁₀

Purity: 98.79%

Color and Shape: Solid

Molecular weight: 872.92

Ref: TM-T11264

FAPI-4

CAS: 2374782-02-0

FAPI-4 is a potent and selective activator of Fc receptor for IgE, which is expressed on the surface of mast cells and basophils. It can be used as a research tool to study the function of Fc receptors or as an inhibitor in the diagnosis and treatment of diseases.
FAPI-4 has been shown to inhibit the activation of phospholipase C, which is involved in triggering inflammatory responses.

Formula: C₄₀H₅₄F₂N₁₀O₁₀

Purity: Min. 95%

Molecular weight: 872.9 g/mol

Ref: 3D-ZUD78202