PROTAC KRAS G12C degrader-2 is a specialized chemical compound designed for targeted protein degradation, specifically aimed at the KRAS G12C mutant protein, which is implicated in various cancers. This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which harness the cell's ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC KRAS G12C degrader-2 typically includes a ligand that binds to the target protein (KRAS G12C) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for a potent and selective reduction of the KRAS G12C protein levels, potentially leading to therapeutic effects in cancer treatment. The compound's efficacy, selectivity, and pharmacokinetic properties are critical for its development as a therapeutic agent, and ongoing research aims to optimize these characteristics for clinical applications.

PROTAC KRAS G12C degrader-2

2378257-72-6: PROTAC KRAS G12C degrader-2 is a specialized chemical compound designed for targeted protein degradation, specifically aimed at the KRAS G12C mutant protein, which is implicated in various cancers. This compound belongs to a class of molecules known as PROTACs (Proteolysis Targeting Chimeras), which harness the cell's ubiquitin-proteasome system to selectively degrade specific proteins. The structure of PROTAC KRAS G12C degrader-2 typically includes a ligand that binds to the target protein (KRAS G12C) and another ligand that recruits an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the target protein. This mechanism allows for a potent and selective reduction of the KRAS G12C protein levels, potentially leading to therapeutic effects in cancer treatment. The compound's efficacy, selectivity, and pharmacokinetic properties are critical for its development as a therapeutic agent, and ongoing research aims to optimize these characteristics for clinical applications.

<p>PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].</p>

CAS 2378257-72-6

PROTAC KRAS G12C degrader-2

PROTAC KRAS G12C degrader-2

Ref: TM-T87266