CAS 2379-57-9

DNQX

Description:

DNQX, or 2,3-dihydroxy-6-nitro-7-sulfamoylquinoxaline, is a synthetic compound primarily recognized for its role as a selective antagonist of the AMPA and kainate subtypes of glutamate receptors in the central nervous system. This compound is often utilized in neuropharmacological research to study excitatory neurotransmission and its implications in various neurological disorders. DNQX is characterized by its ability to inhibit synaptic transmission mediated by glutamate, thereby providing insights into synaptic plasticity and neurotoxicity. It is typically administered in laboratory settings and is known for its relatively high potency and specificity. The compound is soluble in certain organic solvents, which facilitates its use in experimental applications. However, like many pharmacological agents, DNQX must be handled with care due to potential toxicity and the need for precise dosing in research contexts. Overall, DNQX serves as a valuable tool in the exploration of glutamatergic signaling pathways and their roles in health and disease.

Formula: C₈H₄N₄O₆

InChI: InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

InChI key: InChIKey=RWVIMCIPOAXUDG-UHFFFAOYSA-N

SMILES: N(=O)(=O)C1=C(N(=O)=O)C=C2C(=C1)NC(=O)C(=O)N2

Synonyms:

• 1,4-Dihydro-6,7-dinitro-2,3-quinoxalinedione
• 2,3-Quinoxalinediol, 6,7-Dinitro-
• 2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-
• 6,7-Dinitro-2,3-Quinoxalinediol
• 6,7-Dinitro-2,3-dihydroxyquinoxaline
• 6,7-Dinitroquinoxaline-2,3-(1H,4H)-dione
• 6,7-Dinitroquinoxaline-2,3-Diol
• Fg 9041
• 6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione

DNQX

CAS: 2379-57-9

Formula: C₈H₄N₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 252.1406

Ref: IN-DA00BBN4

DNQX

CAS: 2379-57-9

DNQX

Purity: ≥95%

Molecular weight: 252.14g/mol

Ref: 54-BUP11824

DNQX

CAS: 2379-57-9

Formula: C₈H₄N₄O₆

Molecular weight: 252.14

Ref: 7W-GL6449

6,7-Dinitro-1,4-Dihydroquinoxaline-2,3-Dione

CAS: 2379-57-9

6,7-Dinitro-1,4-Dihydroquinoxaline-2,3-Dione

Purity: 98%

Molecular weight: 252.14g/mol

Ref: 54-OR1026539

DNQX

CAS: 2379-57-9

Formula: C₈H₄N₄O₆

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 252.14

Ref: 3B-D6238

DNQX

CAS: 2379-57-9

DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)

Formula: C₈H₄N₄O₆

Purity: 97.27% - 99.1%

Color and Shape: Off-White Powder With A Yellow Tinge

Molecular weight: 252.14

Ref: TM-T7304

6,7-Dinitroquinoxaline-2,3-dione

CAS: 2379-57-9

Stability Store in freezer at -20°C
Applications Potent competitive non-NMDA glutamate receptor antagonist.
References Honore, et al.: Soc. Neurosci Abstr., p 383 (1987), Honore, et al.: Science, 241, 701 (1988), Fong, et al.: Synapse, 4, 88 (1989), Muller, et al.: Science, 242, 1694 (1989)

Formula: C₈H₄N₄O₆

Color and Shape: Neat

Molecular weight: 252.14

Ref: TR-D480000

DNQX

CAS: 2379-57-9

AMPA/ kainate receptor antagonist

Formula: C₈H₄N₄O₆

Purity: Min. 95%

Molecular weight: 252.14 g/mol

Ref: 3D-FD22437