CAS 2387-71-5

Argininosuccinic acid

Description:

Argininosuccinic acid, with the CAS number 2387-71-5, is a naturally occurring amino acid derivative that plays a crucial role in the urea cycle, which is essential for the detoxification of ammonia in the body. It is a diacidic compound, featuring both carboxylic acid and amino functional groups, which contribute to its solubility in water and its ability to participate in various biochemical reactions. The molecular structure includes an arginine and a succinate moiety, reflecting its role as an intermediate in the synthesis of arginine from citrulline. Argininosuccinic acid is typically found in the form of a white crystalline powder and is hygroscopic, meaning it can absorb moisture from the environment. It is important in clinical settings, particularly in the diagnosis and treatment of certain metabolic disorders, such as argininosuccinic aciduria, where its accumulation can indicate a deficiency in the enzymes involved in the urea cycle. Overall, argininosuccinic acid is significant in both metabolic pathways and potential therapeutic applications.

Formula: C₁₀H₁₈N₄O₆

InChI: InChI=1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1

InChI key: InChIKey=KDZOASGQNOPSCU-WDSKDSINSA-N

SMILES: [C@H](NC(NCCC[C@@H](C(O)=O)N)=N)(CC(O)=O)C(O)=O

Synonyms:

• 2387-71-5
• <span class="text-smallcaps">L</span>-Argininosuccinic acid
• <span class="text-smallcaps">L</span>-Arginosuccinic acid
• <span class="text-smallcaps">L</span>-Aspartic acid, N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-, (S)-
• <span class="text-smallcaps">L</span>-Aspartic acid, N-[[[(4S)-4-amino-4-carboxybutyl]amino]iminomethyl]-
• Argininosuccinic acid
• Arginosuccinic acid
• Aspartic acid, N-[(4-amino-4-carboxybutyl)amidino]-, <span class="text-smallcaps">L</span>-
• Descarboxy-Nor-N(Omega)-Hydroxy-L-Arginine
• L-Aspartic acid, N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-, (S)-
• N-[[[(4S)-4-Amino-4-carboxybutyl]amino]iminomethyl]-<span class="text-smallcaps">L</span>-aspartic acid
• L-Argininosuccinic acid
• Aspartic acid, N-[(4-amino-4-carboxybutyl)amidino]-, L-
• L-Aspartic acid, N-[[[(4S)-4-amino-4-carboxybutyl]amino]iminomethyl]-

Argininosuccinic acid

CAS: 2387-71-5

Argininosuccinic acid can be obtained during the urea cycle from citrulline, aspartate, and ATP by argininosuccinic acid synthetase.

Formula: C₁₀H₁₈N₄O₆

Color and Shape: Solid

Molecular weight: 290.27

Ref: TM-T30127

L-Argininosuccinic acid lithium salt

CAS: 2387-71-5

L-Argininosuccinic acid lithium salt is a chemical compound that is used as a metabolic precursor for the synthesis of proteins. It is an intermediate in the urea cycle and is also involved in the biosynthesis of polyamines. L-Argininosuccinic acid lithium salt has been shown to inhibit renal cell cancer, which may be due to its matrix effect on cells and its ability to affect signaling pathways, such as arginine metabolism. The median plasma concentration of L-argininosuccinic acid lithium salt was found to be 0.0006 μmol/L in a study involving healthy adults. L-Argininosuccinic acid lithium salt can be detected in biological samples, such as urine, serum and cerebrospinal fluid (CSF) by mass spectrometry or high performance liquid chromatography (HPLC).

Formula: C₁₀H₁₈N₄O₆·xLi

Purity: Min. 95%

Molecular weight: 290.27 g/mol

Ref: 3D-CAA38771