Zamzetoclax, with the CAS number 2388470-64-0, is a small molecule inhibitor that specifically targets the B-cell lymphoma 2 (BCL-2) protein, which plays a crucial role in regulating apoptosis (programmed cell death). This compound is part of a class of drugs known as BH3 mimetics, designed to mimic the action of pro-apoptotic proteins and promote cell death in cancer cells that overexpress BCL-2, a common feature in various hematological malignancies. Zamzetoclax has shown promise in preclinical and clinical studies, particularly in the treatment of certain types of leukemia and lymphoma. Its mechanism of action involves disrupting the interaction between BCL-2 and pro-apoptotic proteins, thereby restoring the apoptotic pathway in cancer cells. The compound is typically administered orally and is being investigated in combination with other therapies to enhance its efficacy. As with many targeted therapies, monitoring for potential side effects and drug interactions is essential during treatment.

Zamzetoclax

2388470-64-0: Zamzetoclax, with the CAS number 2388470-64-0, is a small molecule inhibitor that specifically targets the B-cell lymphoma 2 (BCL-2) protein, which plays a crucial role in regulating apoptosis (programmed cell death). This compound is part of a class of drugs known as BH3 mimetics, designed to mimic the action of pro-apoptotic proteins and promote cell death in cancer cells that overexpress BCL-2, a common feature in various hematological malignancies. Zamzetoclax has shown promise in preclinical and clinical studies, particularly in the treatment of certain types of leukemia and lymphoma. Its mechanism of action involves disrupting the interaction between BCL-2 and pro-apoptotic proteins, thereby restoring the apoptotic pathway in cancer cells. The compound is typically administered orally and is being investigated in combination with other therapies to enhance its efficacy. As with many targeted therapies, monitoring for potential side effects and drug interactions is essential during treatment.

<p>Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.</p>

CAS 2388470-64-0

Zamzetoclax

Zamzetoclax

Ref: TM-T88291