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CAS 23979-41-1

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(R)-Naproxen

Description:
(R)-Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is characterized by its chiral structure, with the (R)-enantiomer being the active form that exhibits greater potency compared to its (S)-counterpart. The compound is typically presented as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water. Its mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, leading to a decrease in the synthesis of prostaglandins, which are mediators of inflammation and pain. (R)-Naproxen is commonly used to treat conditions such as arthritis, menstrual pain, and other inflammatory disorders. It is important to note that, like other NSAIDs, it may have side effects, including gastrointestinal issues and cardiovascular risks, particularly with long-term use. The compound is often administered in various formulations, including tablets and extended-release forms, to provide sustained therapeutic effects.
Formula:C14H14O3
InChI:InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1
InChI key:InChIKey=CMWTZPSULFXXJA-SECBINFHSA-N
SMILES:[C@@H](C(O)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
Synonyms:
  • (-)-(R)-2-(6-Methoxy-2-naphthyl)propionic acid
  • (-)-2-(6-Methoxy-2-naphthyl)propionic acid
  • (-)-6-Methoxy-α-methyl-2-naphthaleneacetic acid
  • (-)-Naproxen
  • (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid
  • (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
  • (R)-6-Methoxy-alpha-methylnaphthalene-1-acetic acid
  • (αR)-6-Methoxy-α-methyl-2-naphthaleneacetic acid
  • 2-(6-Methoxynaphthalen-1-Yl)Propanoic Acid
  • 2-Naphthaleneacetic acid 6-methoxy-α-methyl-, (αR)-
  • See more synonyms
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