CAS 2408339-39-7

1-Piperazineacetamide, 4-[4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorobenzoyl]-N-[9-[[(1S)-1-[[(2S,4R)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]amino]-9-oxononyl]-

Description:

1-Piperazineacetamide, 4-[4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorobenzoyl]-N-[9-[[(1S)-1-[[(2S,4R)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]amino]-9-oxononyl]- is a complex organic compound characterized by its multi-functional structure, which includes piperazine, imidazo, and thiazole moieties. This compound likely exhibits a range of biological activities due to its intricate arrangement of functional groups, which may interact with various biological targets. Its molecular structure suggests potential applications in medicinal chemistry, particularly in drug development, where such compounds are often designed to modulate specific biological pathways. The presence of fluorine and other substituents may enhance its pharmacokinetic properties, such as solubility and bioavailability. Additionally, the compound's stereochemistry, indicated by the (1S) and (2S,4R) designations, may influence its biological activity and interaction with receptors. Overall, this compound represents a significant area of interest for researchers exploring novel therapeutic agents.

Formula: C₅₆H₇₀FN₁₃O₆S

Synonyms:

• 1-Piperazineacetamide, 4-[4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorobenzoyl]-N-[9-[[(1S)-1-[[(2S,4R)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]amino]-9-oxononyl]-

MS105

CAS: 2408339-39-7

MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.

Formula: C₅₆H₇₀FN₁₃O₆S

Color and Shape: Solid

Molecular weight: 1072.30

Ref: TM-T207347