CAS 2409140-12-9

N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide

Description:

N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups and heterocycles. This substance features a sulfonamide group, which is known for its biological activity, particularly in medicinal chemistry. The presence of a pyrimidine and a pyrrolo[2,3-b]pyridine moiety suggests potential interactions with biological targets, making it of interest in drug discovery. The difluorophenyl group may enhance lipophilicity and influence the compound's pharmacokinetic properties. Additionally, the cyclopropyl group can contribute to the compound's conformational flexibility and may affect its binding affinity to target proteins. Overall, this compound's unique structural features may confer specific biological activities, warranting further investigation in the context of therapeutic applications.

Formula: C₂₄H₂₁F₂N₅O₃S

Synonyms:

• 1-Propanesulfonamide, N-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,6-difluorophenyl]-
• N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide

HRX-0233

CAS: 2409140-12-9

HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.

Formula: C₂₄H₂₁F₂N₅O₃S

Color and Shape: Solid

Molecular weight: 497.52

Ref: TM-T200053