CAS 2410-93-7: Methopterin

Description:Methopterin, also known as 4-amino-4-deoxy-N10-methylpteroylglutamic acid, is a folate analog and a member of the antifolate class of compounds. It is primarily recognized for its role as an inhibitor of dihydrofolate reductase, an enzyme critical in the synthesis of nucleic acids. Methopterin is characterized by its complex structure, which includes a pteridine ring, a para-aminobenzoic acid moiety, and a glutamic acid side chain. This compound is often utilized in the treatment of certain cancers and autoimmune diseases due to its ability to interfere with cellular proliferation. Methopterin is soluble in water and exhibits a relatively low molecular weight. Its pharmacological effects are attributed to its ability to mimic natural folate, thereby disrupting folate metabolism in rapidly dividing cells. While it has therapeutic applications, methopterin can also lead to side effects, necessitating careful monitoring during treatment. Overall, methopterin serves as an important tool in medical chemistry, particularly in oncology and immunology.

Formula:C₂₀H₂₁N₇O₆

InChI:InChI=1S/C20H21N7O6/c1-27(9-11-8-22-16-15(23-11)18(31)26-20(21)25-16)12-4-2-10(3-5-12)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,8,13H,6-7,9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H3,21,22,25,26,31)/t13-/m0/s1

InChI key:InChIKey=HLIXOCXUWGDBNP-ZDUSSCGKSA-N

SMILES:O=C1N=C(N=C2NC=C(N=C12)CN(C3=CC=C(C=C3)C(=O)NC(C(=O)O)CCC(=O)O)C)N

Synonyms:
10-Methylfolic acid
10-Methylpteroylglutamic acid
L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, L-
Glutamic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
Methopterin
Methopterine
N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
See more synonyms
N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)-methyl]methylamino]benzoyl]glutamic Acid
N10-Methylfolic acid
N10-Methylpteroylglutamic acid
NSC 107144
glutamic acid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, L-
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Found 8 products.

Product data	Purity	Price range	Estimated delivery
Methotrexate impurity C CRS REF: 41-Y0000663CAS: 2410-93-7	- - -	115.00 €	Wed 19 Mar 25
Methotrexate Related Compound C ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzamido) pentanedioic acid) REF: 45-1414036CAS: 2410-93-7	- - -	1,477.00 €	Thu 20 Mar 25
Methopterin REF: TM-T20338CAS: 2410-93-7	98%	To inquire	Mon 24 Mar 25
(2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic Acid (N-Methylfolic Acid, Methopterin) REF: 86-MM0040.06CAS: 2410-93-7	- - -	884.00 €	Mon 24 Mar 25
Methotrexate EP Impurity C (Methotrexate USP Related Compound C) REF: 4Z-M-704CAS: 2410-93-7	- - -	To inquire	Fri 28 Mar 25
Methopterine (>90%) REF: TR-M305370CAS: 2410-93-7	>90%	351.00 €~2,238.00 €	Mon 31 Mar 25
Methopterine-d3 REF: TR-M305372CAS: 2410-93-7	- - -	287.00 €~1,904.00 €	Wed 09 Apr 25
Methotrexate Related Compound C REF: 3D-CAA41093CAS: 2410-93-7	Min. 95%	104.00 €~1,855.00 €	Fri 16 May 25