CAS 24121-01-5

2'-O-methylguanosine 5'-(dihydrogen phosphate)

Description:

2'-O-methylguanosine 5'-(dihydrogen phosphate) is a modified nucleoside that plays a significant role in various biochemical processes, particularly in RNA biology. This compound features a guanosine base with a methyl group attached to the 2' position of the ribose sugar, which enhances its stability and influences its interactions with other biomolecules. The presence of a phosphate group at the 5' position is crucial for its function in nucleic acid synthesis and signaling pathways. This modification can affect the secondary structure of RNA, impacting its folding and function. Additionally, 2'-O-methylguanosine is often found in the cap structure of eukaryotic mRNA, contributing to mRNA stability and translation efficiency. Its unique characteristics make it a valuable tool in molecular biology and therapeutic applications, particularly in the development of RNA-based drugs and vaccines. Overall, this compound exemplifies the intricate modifications that nucleosides can undergo, which are essential for the regulation of gene expression and cellular processes.

Formula: C₁₁H₁₆N₅O₈P

InChI: InChI=1S/C11H16N5O8P/c1-22-7-6(17)4(2-23-25(19,20)21)24-10(7)16-3-13-5-8(16)14-11(12)15-9(5)18/h3-4,6-7,10,17H,2H2,1H3,(H2,19,20,21)(H3,12,14,15,18)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=YPMKZCOIEXUDSS-KQYNXXCUSA-N

SMILES: O(C)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(=O)(O)O)[C@H]1O

Synonyms:

• 2'-O-Methyl-2'-guanosine-5'-monophosphate
• 2′-O-Methyl-5′-guanylic acid
• 2′-O-Methylguanosine 5′-monophosphate
• 2′-O-Methylguanosine 5′-phosphate
• 2′-O-Methylguanylic acid
• 5′-Guanylic acid, 2′-O-methyl-
• Guanosine, 2′-O-methyl-, 5′-(dihydrogen phosphate)
• Guanosine, 2′-O-methyl-, 5′-phosphate
• 2'-O-Methyl-Guanosine-5'-monophosphate, Triethylamine salt
• 2'-O-Me-GMP
• 2'-O-Methylguanosine 5'-monophosphate triethylammonium salt

2'-O-Methylguanosine 5'-monophosphate triethylammonium

CAS: 24121-01-5

2'-O-Methylguanosine 5'-monophosphate triethylammonium salt is a phosphate group containing nucleotide that is found in human urine. It can be used as a biomarker for the detection of non-Hodgkin's lymphoma. 2'-O-Methylguanosine 5'-monophosphate triethylammonium salt has been shown to coelute with guanosine in urine samples from patients with cancer, and also shows sensitivity to elements such as arsenic, mercury, and lead. This nucleotide is methylated in many types of cancer cells, which makes it useful for radioimmunoassays and antibody production.

Formula: C₁₁H₁₆N₅O₈P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 377.25 g/mol

Ref: 3D-NM71636

2'-O-Methylguanosine 5'-monophosphate sodium

CAS: 24121-01-5

2'-O-Methylguanosine 5'-monophosphate sodium is a nucleoside analog that has been shown to inhibit the growth of human cancer cells. It is a modified monophosphate nucleotide, which is synthesized by the chemical modification of guanosine with 2'-O-methylation at the 5' position and phosphorylation at the 3' position. This drug is not active against viruses and may be used as an anticancer agent. 2'-O-Methylguanosine 5'-monophosphate sodium has also been shown to be effective in treating hepatitis B virus infection. The drug may act as an antiviral agent by interfering with viral DNA synthesis, causing viral particles to aggregate, or by inhibiting viral DNA polymerase activity.

Purity: Min. 95%

Ref: 3D-NM182233