CAS 2413455-99-7

Benzenemethanesulfonamide, N-[2,3,6-trifluoro-4-[[3-[2-[[(3S,5S)-5-fluoro-3-piperidinyl]amino]-4-pyrimidinyl]-2-pyridinyl]oxy]phenyl]-

Description:

Benzenemethanesulfonamide, N-[2,3,6-trifluoro-4-[[3-[2-[[(3S,5S)-5-fluoro-3-piperidinyl]amino]-4-pyrimidinyl]-2-pyridinyl]oxy]phenyl]- (CAS 2413455-99-7) is a complex organic compound characterized by its sulfonamide functional group, which is known for its antibacterial properties. The presence of multiple fluorine atoms in its structure enhances lipophilicity and may influence its biological activity, potentially improving its pharmacokinetic properties. The compound features a piperidine ring, which is often associated with various biological activities, including potential therapeutic effects. Additionally, the presence of pyrimidine and pyridine moieties suggests that it may interact with biological targets such as enzymes or receptors. Its intricate structure indicates potential for use in medicinal chemistry, particularly in the development of pharmaceuticals. The compound's solubility, stability, and reactivity would depend on its specific molecular interactions, making it a subject of interest for further research in drug design and development.

Formula: C₂₇H₂₄F₄N₆O₃S

Synonyms:

• G-5758
• Benzenemethanesulfonamide, N-[2,3,6-trifluoro-4-[[3-[2-[[(3S,5S)-5-fluoro-3-piperidinyl]amino]-4-pyrimidinyl]-2-pyridinyl]oxy]phenyl]-

G-5758

CAS: 2413455-99-7

G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.

Formula: C₂₇H₂₄F₄N₆O₃S

Color and Shape: Solid

Molecular weight: 588.58

Ref: TM-T87983