The chemical substance known as 1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate, with the CAS number 2414349-93-0, is a complex organic compound characterized by its unique structural features. It contains a thieno[3,2-b]pyridine core, which is a fused bicyclic system known for its biological activity. The presence of trifluoromethyl and trifluoromethoxy groups enhances its lipophilicity and may contribute to its pharmacological properties. The piperidine moiety adds to the compound's basicity and potential interactions with biological targets. The methylcarbamoyl and carbamate functional groups suggest that this compound may exhibit specific reactivity and solubility characteristics, making it of interest in medicinal chemistry. Overall, the combination of these functional groups and structural elements indicates that this compound may possess significant biological activity, potentially making it a candidate for further research in drug development or therapeutic applications.

UJN49930 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 μM for all). In vivo, UJN49930 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.

1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate

2414349-93-0: The chemical substance known as 1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate, with the CAS number 2414349-93-0, is a complex organic compound characterized by its unique structural features. It contains a thieno[3,2-b]pyridine core, which is a fused bicyclic system known for its biological activity. The presence of trifluoromethyl and trifluoromethoxy groups enhances its lipophilicity and may contribute to its pharmacological properties. The piperidine moiety adds to the compound's basicity and potential interactions with biological targets. The methylcarbamoyl and carbamate functional groups suggest that this compound may exhibit specific reactivity and solubility characteristics, making it of interest in medicinal chemistry. Overall, the combination of these functional groups and structural elements indicates that this compound may possess significant biological activity, potentially making it a candidate for further research in drug development or therapeutic applications.

<p>UGT8-IN-1 is a brain-permeable and orally-active inhibitor that specifically targets the ceramide galactosyltransferase enzyme (UGT8). By inhibiting UGT8, this compound has the potential to be employed in research pertaining to lysosomal storage disorders.</p>

CAS 2414349-93-0

1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate

UGT8-IN-1

Ref: TM-T40046