CAS 241800-97-5

ZONIPORIDE DIHYDROCHLORIDE

Description:

Zoniporide dihydrochloride is a chemical compound primarily recognized for its role as a selective inhibitor of the sodium-hydrogen exchanger (NHE) isoform 1, which is involved in various physiological processes, including cardiac function and cellular pH regulation. This compound is often studied in the context of cardiovascular research due to its potential therapeutic applications in conditions such as heart failure and ischemia. Zoniporide dihydrochloride is typically characterized by its high solubility in water, which facilitates its use in biological assays and pharmacological studies. The dihydrochloride form indicates the presence of two hydrochloride ions, enhancing its stability and solubility. As with many pharmacological agents, the safety profile, dosage, and specific interactions with biological systems are critical areas of research. Overall, Zoniporide dihydrochloride represents a significant interest in medicinal chemistry, particularly for its targeted action on ion transport mechanisms in cells.

Formula: C₁₇H₁₆N₆O·2HCl

Synonyms:

• 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide:hydrochloride
• [1-(QUINOLIN-5-YL)-5-CYCLOPROPYL-1H-PYRAZOLE-4-CARBONYL]GUANIDINE DIHYDROCHLORIDE
• [1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride
• ZONIPORIDE DIHYDROCHLORIDE

Zoniporide hydrochloride

CAS: 241800-97-5

Zoniporide hydrochloride

Purity: ≥98%

Molecular weight: 356.81g/mol

Ref: 54-BUP01109

Zoniporide monohydrochloride monohydrate

CAS: 241800-97-5

Formula: C₁₀H₁₀N₂O₃

Molecular weight: 206.20

Ref: 7W-GP7569

Zoniporide hydrochloride

CAS: 241800-97-5

Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).

Formula: C₁₇H₁₇ClN₆O

Purity: 99.68%

Color and Shape: Solid

Molecular weight: 356.81

Ref: TM-T21996

Zoniporide Hydrochloride

Controlled Product

CAS: 241800-97-5

Applications Zoniporide is a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury.
References Ross, T.W., et al.: Cardiovascular. Drug. Reviews., 21, 17 (2003); Deepak, D., et al.: Drug. Metabol. Dispos., 38, 641 (2010);

Formula: C₁₇H₁₆N₆O₂•(HCl)

Color and Shape: Neat

Molecular weight: 356.81

Ref: TR-Z680000