CAS 2421260-43-5

2,6-Piperidinedione, 3-[1,3-dihydro-5-[4-[[1-[4-[(1E)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-1-oxo-2H-isoindol-2-yl]-, (3S)-

Formula: C₄₅H₄₉N₅O₄

Synonyms:

• 2,6-Piperidinedione, 3-[1,3-dihydro-5-[4-[[1-[4-[(1E)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-1-oxo-2H-isoindol-2-yl]-, (3S)-

PROTAC ERα Degrader-10

CAS: 2421260-43-5

PROTACERα Degrader-10 (Compound 160a) is an orally bioavailable ERα degrader with a DC50 of 0.37-1.1 nM in MCF7, T47D, and CAMA-1 cells. It demonstrates antitumor activity in mouse models.

Formula: C₄₅H₄₉N₅O₄

Molecular weight: 723.9

Ref: TM-T203319