CAS 2423948-94-9

Immunoglobulin G1 [236-alanine,237-alanine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein) (human monoclonal LY3832479 γ1-chain), disulfide with human monoclonal LY3832479 κ-chain, dimer

Description:

Immunoglobulin G1 (IgG1) is a type of antibody that plays a crucial role in the immune response, particularly in recognizing and neutralizing pathogens. The specific substance you mentioned, anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein) (human monoclonal LY3832479), is a monoclonal antibody designed to target the spike protein of the SARS-CoV-2 virus, which is responsible for COVID-19. This antibody is engineered to enhance its affinity and specificity for the spike protein, facilitating effective neutralization of the virus. The dimeric form indicates that it consists of two identical antibody molecules linked by disulfide bonds, which is typical for IgG antibodies, enhancing their stability and functionality. The presence of alanine residues at positions 236 and 237 suggests modifications that may influence the antibody's binding characteristics or stability. Overall, this monoclonal antibody represents a targeted therapeutic approach in combating COVID-19 by preventing viral entry into host cells.

Formula: Unspecified

Synonyms:

• LY CoV016
• Immunoglobulin G1 [236-alanine,237-alanine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein) (human monoclonal LY3832479 γ1-chain), disulfide with human monoclonal LY3832479 κ-chain, dimer
• Immunoglobulin G1 [236-alanine,237-alanine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor-binding domain) (human monoclonal JS016 γ1-chain), disulfide with human monoclonal JS016 κ-chain, dimer
• LY 3832479
• Etesevimab

Etesevimab

CAS: 2423948-94-9

Etesevimab (JS016) is a recombinant human IgG1 monoclonal antibody that neutralizes SARS-CoV-2.

Color and Shape: Liquid

Ref: TM-T76852