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CAS 2438-32-6

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(S)-(+)-chlorpheniramine maleate

Description:
(S)-(+)-chlorpheniramine maleate is an antihistamine commonly used to alleviate allergy symptoms. It is a salt formed from chlorpheniramine, a first-generation antihistamine, and maleic acid. This compound is characterized by its ability to selectively block H1 histamine receptors, thereby reducing symptoms such as sneezing, itching, and runny nose. It is typically administered orally and is known for its sedative effects due to its ability to cross the blood-brain barrier. The substance is a white to off-white crystalline powder, soluble in water, and has a specific optical rotation, indicating its chiral nature. Its pharmacological profile includes anticholinergic properties, which can lead to side effects such as dry mouth and drowsiness. As with many antihistamines, caution is advised when used in conjunction with other central nervous system depressants. Overall, (S)-(+)-chlorpheniramine maleate is an effective medication for managing allergic reactions, but it should be used under medical supervision to mitigate potential side effects.
Formula:C20H23ClN2O4
InChI:InChI=1/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
SMILES:[C@H](CCN(C)C)(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.C(=C\C(O)=O)\C(O)=O
Synonyms:
  • (+)-Chlorpheniramine maleate
  • (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
  • (S)-3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (S)-, (Z)-2-butenedioate (1:1)
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (γS)-, (2Z)-2-butenedioate (1:1)
  • Dexchloropheniramine maleate
  • Dexchlorpheniramine Maleate
  • Dexchlorpheniramine hydrogen maleate
  • Dextrochlorpheniramine maleate
  • Fortamine
  • See more synonyms
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