CAS 2438-72-4

Bufexamac

Description:

Bufexamac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is characterized by its ability to inhibit the synthesis of prostaglandins, which are compounds involved in inflammation and pain signaling. Bufexamac is often utilized in topical formulations for the treatment of various skin conditions, including dermatitis and eczema, due to its localized action and reduced systemic side effects compared to oral NSAIDs. The substance is typically presented as a white to off-white crystalline powder, with moderate solubility in organic solvents and limited solubility in water. Its mechanism of action involves the inhibition of cyclooxygenase enzymes, leading to decreased production of inflammatory mediators. While generally well-tolerated, bufexamac may cause skin irritation or allergic reactions in some individuals. As with any medication, it is essential to use bufexamac under appropriate medical guidance to ensure safety and efficacy.

Formula: C₁₂H₁₇NO₃

InChI: InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

InChI key: InChIKey=MXJWRABVEGLYDG-UHFFFAOYSA-N

SMILES: C(C(NO)=O)C1=CC=C(OCCCC)C=C1

Synonyms:

• 2-(4-Butoxyphenyl)Acetohydroxamic Acid
• 2-(4-butoxyphenyl)-N-hydroxyacetamide
• 2-(p-Butoxyphenyl)acetohydroxamic acid
• 4-Butoxy-N-hydroxybenzeneacetamide
• 4-Butoxyphenylacethydroxamic acid
• Acetohydroxamic acid, 2-(p-butoxyphenyl)-
• Anderm
• Benzeneacetamide, 4-butoxy-N-hydroxy-
• Bufexamic acid
• Cp 1044J3
• Droxarol
• Droxaryl
• Feximac
• Flogocid
• Flogocid N plastigel
• Malipuran
• Mofenar
• Norfemac
• Parfenac
• Parfenal
• Trolab
• p-Butoxyphenylacethydroxamic acid

Bufexamac

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 223.27

Ref: 3B-B4179

Bufexamac 1.0 mg/ml in Acetonitrile

CAS: 2438-72-4

Color and Shape: Single Solution

Ref: 61-AMP0179.00-11

Bufexamac

CAS: 2438-72-4

Color and Shape: Neat

Ref: 61-FOR0179.00

BUFEXAMAC CRS

CAS: 2438-72-4

BUFEXAMAC CRS

Formula: C₁₂H₁₇NO₃

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 223.2683

Ref: 41-B1156000

Bufexamac

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 223.2683

Ref: IN-DA007NMA

Bufexamac

CAS: 2438-72-4

Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.

Formula: C₁₂H₁₇NO₃

Purity: 99.73%

Color and Shape: Acicular Crystal

Molecular weight: 223.27

Ref: TM-T0867

2-(4-Butoxyphenyl)-N-Hydroxyacetamide

CAS: 2438-72-4

2-(4-Butoxyphenyl)-N-Hydroxyacetamide

Purity: 98%

Molecular weight: 223.27g/mol

Ref: 54-OR1009760

Bufexamac

CAS: 2438-72-4

Bufexamac

Purity: ≥95%

Molecular weight: 223.27g/mol

Ref: 54-BUP17118

Bufexamac

Controlled Product

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Color and Shape: Neat

Molecular weight: 223.27

Ref: 86-MM0179.00

Bufexamac

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Color and Shape: Neat

Molecular weight: 223.27

Ref: 04-C10830500

Bufexamac

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Purity: ≥ 97.0%

Color and Shape: White to off-white powder or crystals

Molecular weight: 223.27

Ref: 7W-GP6678

Bufexamac

Controlled Product

CAS: 2438-72-4

Applications Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.
References Bantscheff, M. et al.: Nature Biotechnol., 29, 255 (2011); Kranke, B. et al.: Cont. Derm., 36, 212 (1997);

Formula: C₁₂H₁₇NO₃

Color and Shape: White

Molecular weight: 223.27

Ref: TR-B689390

2-(4-Butoxyphenyl)-N-hydroxyacetamide

CAS: 2438-72-4

Formula: C₁₂H₁₇NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 223.272

Ref: 10-F318152