CAS 244-63-3

β-Carboline

Description:

β-Carboline, with the CAS number 244-63-3, is a naturally occurring alkaloid that belongs to the class of compounds known as β-carbolines. It is characterized by a fused bicyclic structure that includes a pyridine and an indole ring. This compound is typically found in various plants and is known for its presence in foods such as grilled meats, where it forms during the cooking process. β-Carboline exhibits a range of biological activities, including potential neuroprotective effects, and has been studied for its role in various neurological disorders. Additionally, it has been implicated in the modulation of neurotransmitter systems, particularly those involving serotonin and dopamine. The compound is also of interest in pharmacology due to its potential as a therapeutic agent, with research exploring its effects on anxiety, depression, and other mental health conditions. Its chemical properties include being a weak base and having the ability to form salts with acids, which can influence its solubility and bioavailability in different environments.

Formula: C₁₁H₈N₂

InChI: InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChI key: InChIKey=AIFRHYZBTHREPW-UHFFFAOYSA-N

SMILES: C1=2C=3C(NC1=CC=CC2)=CN=CC3

Synonyms:

• 2,9-Diazafluorene
• 2-Azacarbazole
• 9H-Pyrido[3,4-B]Indole
• 9H-Pyrido[3,4-b]indol
• 9H-pirido[3,4-b]indol
• Carbazoline
• Norharmane
• Nsc 84417
• β-Carboline
• Norharman

9H-Pyrido[3,4-b]indole

CAS: 244-63-3

Formula: C₁₁H₈N₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 168.1946

Ref: IN-DA0034F8

Norharmane

CAS: 244-63-3

Norharmane

Purity: ≥95%

Molecular weight: 168.19g/mol

Ref: 54-BUP17643

9H-Pyrido[3,4-b]Indole

CAS: 244-63-3

9H-Pyrido[3,4-b]Indole

Purity: 98%

Molecular weight: 168.19g/mol

Ref: 54-OR1012173

9H-Pyrido[3,4-b]indole

CAS: 244-63-3

Purity: 95.0%

Color and Shape: Solid, White to slightly pale yellow powder

Molecular weight: 168.19900512695312

Ref: 10-F230515

9H-Pyrido[3,4-b]indole

CAS: 244-63-3

Formula: C₁₁H₈N₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 168.20

Ref: 3B-P1121

Norharmane

Controlled Product

CAS: 244-63-3

Formula: C₁₁H₈N₂

Color and Shape: Neat

Molecular weight: 168.19

Ref: 04-C15643000

Norharmane

CAS: 244-63-3

Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.

Formula: C₁₁H₈N₂

Purity: 95.16% - 99.53%

Color and Shape: Solid

Molecular weight: 168.19

Ref: TM-T4024

Norharman

CAS: 244-63-3

Formula: C₁₁H₈N₂

Molecular weight: 168.20

Ref: 4Z-H-104005

Norharmane

CAS: 244-63-3

Formula: C₁₁H₈N₂

Molecular weight: 168.19

Ref: 7W-GL5091

Nor Harmane

Controlled Product

CAS: 244-63-3

Applications The compund has cytotoxic effects.
References Elfarra, A., et al.: Drug Metab. Dispos., 26, 779 (1998), Da Costa, A., et al.: Biocell, 23, 65 (1999), Janetzky, B., et al.: Drug Dev. Res., 46, 51 (1999), Kutty, R., et al.: Toxicol. Appl. Pharmacol., 107, 377 (1991), Riederer, F., et al.: J. Neurochem., 81, 814 (2002), Schott, Y., et al.: Bioorg. Med. Chem. Lett., 16, 5840 (2006)

Formula: C₁₁H₈N₂

Color and Shape: Off-White To Light Brown

Molecular weight: 168.19

Ref: TR-N700000

Norharman, free base

CAS: 244-63-3

Norharmane and Harmane are both members of the class of β-carbolines. They are known to be endogenously formed body constituents, but external sources have also been identified. For example, tobacco smoke and certain processed meat contain small amounts of the compounds (J. Chromatogr. B). Plants containing these alkaloids are originally used in hallucinogenic drinks or snuffs in religious ceremonies particularly in the Amazon basin. The neurological effects of β-carbolines are well characterized at the molecular level. In addition, Norharmane and Harmane show molecular similarity to Parkinson-inducing neurotoxins and as a result these compounds have been studied extensively to identify their connection to idiopathic Parkinson’s disease. Indeed, it has been noted that the concentration of Harmane in the blood seems to be elevated in Parkinson’s disease patients.

Formula: C₁₁H₈N₂

Purity: Min. 98 Area-%

Molecular weight: 168.20 g/mol

Ref: 3D-N-8700

Norharman - free base

CAS: 244-63-3

Norharman - free base is a chemical compound that is categorized as a β-carboline alkaloid. It occurs naturally in various plant and animal sources, such as tobacco smoke and cooked foods, indicating its broad environmental presence. The compound is synthesized in laboratory settings for precise examination and experimentation.

Purity: Min. 95%

Ref: 3D-XN175452

Nor Harmane

CAS: 244-63-3

Formula: C₁₁H₈N₂

Molecular weight: 168.20

Ref: 4Z-H-154