CAS 244133-31-1

VRT-043198

Description:

VRT-043198, with the CAS number 244133-31-1, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. The compound is often studied for its role as a selective inhibitor, potentially impacting certain biological pathways or targets within cells. Its solubility, stability, and reactivity are important characteristics that influence its efficacy and safety profile in pharmacological contexts. Additionally, VRT-043198 may exhibit specific pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME), which are crucial for understanding its behavior in biological systems. Research into this compound may also explore its interactions with other molecules, its mechanism of action, and its potential side effects. Overall, VRT-043198 represents a significant area of interest for researchers aiming to develop new therapeutic agents.

VRT 043198

Controlled Product

CAS: 244133-31-1

Applications VRT 043198, is an active metabolite of VX-765 (V900605), which is a Caspase inhibitor.
References Adriaenssens Y, et al.: Org Biomol Chem. 2017 Sep 13;15(35):7456-7473. doi: 10.1039/c7ob01403a. PubMed PMID: 28837200.

Formula: C₂₂H₂₉ClN₄O₆

Color and Shape: White To Off-White

Molecular weight: 480.18

Ref: TR-V375025

VRT 043198

CAS: 244133-31-1

An inhibitor of caspase-1 and active metabolite of VX-765. Blocks lipopolysaccharide-mediated release of cytokines. Suppresses release of interleukins IL-1β and IL-18. Reduced inflammatory cytokines, such as IL-1α, tumor necrosis factor-α, IL-6 and IL-8, observed in in vivo models of rheumatoid arthritis and skin inflammation.

Formula: C₂₂H₂₉ClN₄O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 480.94 g/mol

Ref: 3D-BV165183

VRT-043198

CAS: 244133-31-1

VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.

Formula: C₂₂H₂₉ClN₄O₆

Color and Shape: Solid

Molecular weight: 480.94

Ref: TM-T69632