Mcl-1 inhibitor 12, identified by its CAS number 2445466-24-8, is a small molecule designed to inhibit the Mcl-1 protein, which is a member of the Bcl-2 family of proteins involved in regulating apoptosis (programmed cell death). This compound is of particular interest in cancer research, as Mcl-1 is often overexpressed in various malignancies, contributing to tumor survival and resistance to chemotherapy. The characteristics of Mcl-1 inhibitor 12 include its ability to selectively bind to the Mcl-1 protein, thereby promoting apoptosis in cancer cells that rely on Mcl-1 for survival. The compound typically exhibits low toxicity to normal cells, making it a promising candidate for targeted cancer therapies. Additionally, its chemical structure may include specific functional groups that enhance its binding affinity and selectivity for Mcl-1. Ongoing research aims to further elucidate its pharmacokinetics, efficacy, and potential side effects in clinical settings, contributing to the development of novel therapeutic strategies against cancer.

Mcl-1 inhibitor 12

2445466-24-8: Mcl-1 inhibitor 12, identified by its CAS number 2445466-24-8, is a small molecule designed to inhibit the Mcl-1 protein, which is a member of the Bcl-2 family of proteins involved in regulating apoptosis (programmed cell death). This compound is of particular interest in cancer research, as Mcl-1 is often overexpressed in various malignancies, contributing to tumor survival and resistance to chemotherapy. The characteristics of Mcl-1 inhibitor 12 include its ability to selectively bind to the Mcl-1 protein, thereby promoting apoptosis in cancer cells that rely on Mcl-1 for survival. The compound typically exhibits low toxicity to normal cells, making it a promising candidate for targeted cancer therapies. Additionally, its chemical structure may include specific functional groups that enhance its binding affinity and selectivity for Mcl-1. Ongoing research aims to further elucidate its pharmacokinetics, efficacy, and potential side effects in clinical settings, contributing to the development of novel therapeutic strategies against cancer.

<p>Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].</p>

CAS 2445466-24-8

Mcl-1 inhibitor 12

Mcl-1 inhibitor 12

Ref: TM-T75143