CAS 2448-68-2

Pipamperone dihydrochloride

Description:

Pipamperone dihydrochloride is a chemical compound primarily recognized for its use as an antipsychotic medication. It belongs to the class of butyrophenones and is characterized by its ability to antagonize dopamine receptors, particularly the D2 subtype, which is significant in the treatment of various psychiatric disorders. The dihydrochloride form indicates that the compound is a salt, enhancing its solubility and stability in pharmaceutical formulations. Pipamperone exhibits a relatively long half-life, allowing for once-daily dosing in clinical settings. Its pharmacological profile includes sedative and anxiolytic properties, making it useful in managing symptoms of schizophrenia and other related conditions. Additionally, it may have effects on other neurotransmitter systems, including serotonin and norepinephrine, contributing to its therapeutic effects. As with many antipsychotics, potential side effects can include sedation, weight gain, and extrapyramidal symptoms, necessitating careful monitoring during treatment. Overall, pipamperone dihydrochloride is an important compound in psychopharmacology, with a well-established role in managing severe mental health disorders.

Formula: C₂₁H₃₀FN₃O₂·2ClH

InChI: InChI=1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H

InChI key: InChIKey=BMXXSXQVMCXGJM-UHFFFAOYSA-N

SMILES: C(N)(=O)C1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)N3CCCCC3.Cl

Synonyms:

• (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(p-fluorobenzoyl)propyl)-, dihydrochloride
• 4'-Carbamoyl-1'-[4-(4-Fluorophenyl)-4-Oxobutyl]-1,4'-Bipiperidinium Dichloride
• Nsc 170981
• Pipamperone HCl
• Pipamperone dichlorhydrate
• Pipamperone dihydrochloride
• Pipamperone hydrochloride
• Piperonil
• Propitan
• [1,4′-Bipiperidine]-4′-carboxamide, 1′-[4-(4-fluorophenyl)-4-oxobutyl]-, dihydrochloride
• [1,4′-Bipiperidine]-4′-carboxamide, 1′-[4-(4-fluorophenyl)-4-oxobutyl]-, hydrochloride (1:2)

[1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]-, hydrochloride (1:2)

CAS: 2448-68-2

Formula: C₂₁H₃₂Cl₂FN₃O₂

Color and Shape: Solid

Molecular weight: 448.4021

Ref: IN-DA002OAA

Pipamperone dihydrochloride

CAS: 2448-68-2

Formula: C₂₁H₃₀N₃O₂F·2HCl

Molecular weight: 448.40

Ref: 7W-GP4634

Pipamperone DiHCl

CAS: 2448-68-2

Formula: C₂₁H₃₀FN₃O₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 375.49 2*36.46

Ref: 4Z-P-161001

Pipamperone HCl

CAS: 2448-68-2

Pipamperone blocks 5-HT2A/B/C, D2/D3/D4, α1/α2 receptors; favors 5-HT2A/D4 over D2; negligible affinity for H1, mACh. Highly selective at low doses.

Formula: C₂₁H₃₁ClFN₃O₂

Color and Shape: Solid

Molecular weight: 411.95

Ref: TM-T28417

Pipamperone Dihydrochloride

Controlled Product

CAS: 2448-68-2

Applications Antipsychotic.
References Steinijans, V., et al.: Eur. J. Clin. Pharm., 24, 127 (1983), Luhmann, I., et al.: Arzneim.-Forsch., 42, 1069 (1992), Hauck, W., et al.: J. Biopharm. Stat., 7, 87 (1997),

Formula: C₂₁H₃₀FN₃O₂·2ClH

Color and Shape: White To Light Yellow

Molecular weight: 448.40

Ref: TR-P475200