CAS 245084-07-5

Genistein 4’-β-D-Glucuronide

Description:

Genistein 4’-β-D-Glucuronide is a glucuronide conjugate of genistein, a naturally occurring isoflavone primarily found in soy products. This compound is characterized by its structure, which includes a genistein moiety linked to a glucuronic acid unit via a β-glycosidic bond. Genistein itself is known for its potential health benefits, including antioxidant, anti-inflammatory, and estrogenic activities. The glucuronidation process enhances the solubility and bioavailability of genistein, facilitating its excretion and potentially modulating its biological effects. Genistein 4’-β-D-Glucuronide is often studied in the context of pharmacokinetics and metabolism, as it represents a significant form of genistein present in biological systems after ingestion. Its properties include being a white to off-white powder, soluble in water, and stable under physiological conditions. Research indicates that this compound may play a role in various health-related mechanisms, including cancer prevention and cardiovascular health, although further studies are needed to fully elucidate its effects and therapeutic potential.

Formula: C₂₁H₁₈O₁₁

Synonyms:

• Genistein-4'-glucuronide
• 4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl β-D-Glucopyranosiduronic Acid
• β-D-Glucopyranosiduronic acid, 4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl
• Genistein 4’-β-D-Glucuronide
• (2S,3S,4S,5R,6S)-6-[4-(5,7-dihydroxy-4-oxochromen-3-yl)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid

Genistein 4’-β-D-Glucuronide

CAS: 245084-07-5

Stability Hygroscopic
Applications Genistein (G350000) metabolite.
References Hosoda, K., et al.: Drug Metab. Disposition, 36, 1485 (2008), Bursztyka, J., et al.: Food Chem., Toxicol., 46, 939 (2008), Hosoda, K., et al.: Anal. Bioanal. Chem., 397, 1563 (2010),

Formula: C₂₁H₁₈O₁₁

Color and Shape: Off-White To Yellow

Molecular weight: 446.36

Ref: TR-G349990

Genistein 4’-β-D-glucuronide

CAS: 245084-07-5

Genistein 4’-β-D-glucuronide is an isoflavonoid that is a natural product of soy and red clover, with estrogenic properties. It has been shown to have the ability to bind to estrogen receptors and inhibit the growth of breast cancer cells. Genistein 4’-β-D-glucuronide has been shown to inhibit the production of estrone sulfate in human breast cells, which may be due to its ability to act as an estrogen receptor antagonist. The isoflavonoid genistein also binds to and inhibits the activity of DNA topoisomerase II enzymes in human breast cells.

Formula: C₂₁H₁₈O₁₁

Purity: Min. 95%

Molecular weight: 446.4 g/mol

Ref: 3D-VJA08407