CAS 245116-90-9

Lidorestat

Description:

Lidorestat is a chemical compound primarily investigated for its potential therapeutic applications, particularly in the treatment of diabetic retinopathy. It functions as an aldose reductase inhibitor, which means it inhibits the enzyme responsible for converting glucose into sorbitol, thereby potentially mitigating complications associated with diabetes. The molecular structure of Lidorestat includes specific functional groups that contribute to its biological activity and pharmacokinetic properties. It is typically characterized by its solubility in organic solvents and limited solubility in water, which can influence its bioavailability. The compound has undergone various preclinical and clinical studies to evaluate its efficacy and safety profile. As with many pharmaceutical agents, understanding its mechanism of action, side effects, and interactions with other medications is crucial for its development and use in clinical settings. Overall, Lidorestat represents a significant focus in research aimed at improving outcomes for patients with diabetes-related complications.

Formula: C₁₈H₁₁F₃N₂O₂S

InChI: InChI=1S/C18H11F3N2O2S/c19-11-6-12(20)18-17(16(11)21)22-14(26-18)5-9-7-23(8-15(24)25)13-4-2-1-3-10(9)13/h1-4,6-7H,5,8H2,(H,24,25)

InChI key: InChIKey=KYHVTMFADJNSGS-UHFFFAOYSA-N

SMILES: C(C=1C=2C(N(CC(O)=O)C1)=CC=CC2)C=3SC=4C(N3)=C(F)C(F)=CC4F

Synonyms:

• 1H-Indole-1-acetic acid, 3-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
• 2-(3-((4,5,7-Trifluorobenzo[d]thiazol-2-yl)methyl)-1H-indol-1-yl)acetic acid
• 3-[(4,5,7-Trifluoro-2-benzothiazolyl)methyl]-1H-indole-1-acetic acid
• 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid
• Eml-676
• Idd-000676-01
• Idd-676
• Lidorestat
• [3-(4,5,7-Trifluorobenzothiazol-2-ylmethyl)indol-1-yl]acetic acid
• {3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl}acetic acid

1H-Indole-1-acetic acid, 3-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-

CAS: 245116-90-9

Formula: C₁₈H₁₁F₃N₂O₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 376.3523

Ref: IN-DA002ODX

2-(3-((4,5,7-TRIFLUOROBENZO[D]THIAZOL-2-YL)METHYL)-1H-INDOL-1-YL)ACETIC ACID

CAS: 245116-90-9

Formula: C₁₈H₁₁F₃N₂O₂S

Purity: 95%

Color and Shape: Liquid, No data available.

Molecular weight: 376.35

Ref: 10-F535782

Lidorestat

Controlled Product

CAS: 245116-90-9

Lidorestat is a naturally occurring compound with potent anti-inflammatory and antioxidant properties. It has been shown to inhibit the activity of enzymes involved in the inflammatory response and protect against oxidative stress in animal models. Lidorestat also demonstrates efficacy in treating diabetic neuropathy, which may be due to its ability to inhibit the production of reactive oxygen species or increase cellular levels of glutathione, an important antioxidant. Lidorestat is poorly absorbed and has a low bioavailability, which may be due to ester linkages or hydroxyl groups on its structure. This makes it a good candidate for drug development as it can serve as a lead molecule in the search for improved drugs targeting inflammatory bowel disease or diabetes.

Formula: C₁₈H₁₁F₃N₂O₂S

Purity: Min. 95%

Molecular weight: 376.35 g/mol

Ref: 3D-FL103933

Lidorestat

CAS: 245116-90-9

Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity.

Formula: C₁₈H₁₁F₃N₂O₂S

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 376.35

Ref: TM-T15756