CAS 2451398-65-3

4-Amino-6-(2-cyclopropylethynyl)-7-[(3R,5S)-5-methyl-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Formula: C₂₈H₃₀N₆O₂

Synonyms:

• 4-Amino-6-(2-cyclopropylethynyl)-7-[(3R,5S)-5-methyl-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

TAS2940 free base

CAS: 2451398-65-3

TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.

Formula: C₂₈H₃₀N₆O₂

Color and Shape: Solid

Molecular weight: 482.58

Ref: TM-T202527