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CAS 2451398-65-3

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    Targetmol
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    TAS2940 free base

    CAS:
    TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.
    Formula:C28H30N6O2
    Molecular weight:482.58

    Ref: TM-T202527