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CAS 24526-64-5

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Nomifensine

Description:
Nomifensine is a chemical compound classified as a monoamine reuptake inhibitor, primarily affecting the neurotransmitters dopamine and norepinephrine. It was initially developed as an antidepressant and is known for its stimulant properties. The substance has a molecular formula that reflects its complex structure, which includes a piperidine ring, contributing to its pharmacological activity. Nomifensine is characterized by its ability to enhance mood and energy levels, making it effective in treating certain mood disorders. However, its use has been limited due to side effects and safety concerns, including the potential for neurotoxicity and adverse cardiovascular effects. As a result, it has been withdrawn from the market in many regions. In terms of physical properties, Nomifensine is typically presented as a white to off-white crystalline powder, soluble in organic solvents but less so in water. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through urine. Overall, while Nomifensine has historical significance in pharmacology, its clinical application is now largely obsolete.
Formula:C16H18N2
InChI:InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
InChI key:InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N
SMILES:NC1=C2C(C(CN(C)C2)C3=CC=CC=C3)=CC=C1
Synonyms:
  • (±)-Nomifensin
  • 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
  • 2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine
  • 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-ylamine
  • 2-Methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
  • 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
  • Isoquinoline, 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-
  • Linamiphen
  • Nomifensine
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