CAS 245501-02-4

4-Carboxy Nevirapine

Controlled Product

CAS: 245501-02-4

Stability Hygroscopic
Applications 4-Carboxy Nevirapine is a metabolite of Nevirapine (N391275); a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Also antiviral.
References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991); Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993); Guay, L.A., et al.: Lancet, 354, 795 (1999); Riska, P., et al.: Drug Metab. Dispos., 27, 895 (1999)

Formula: C₁₅H₁₂N₄O₃

Color and Shape: Neat

Molecular weight: 296.28

Ref: TR-C181050

4-Carboxy nevirapine

CAS: 245501-02-4

4-Carboxy nevirapine is a synthetic drug product that is used as an analytical reference standard for the impurity 4-carboxynevirapine. It has been shown to have niche applications in pharmacopoeia and natural product research and development. The metabolite 4-carboxynevirapine can be synthesized from nevirapine which is found in the plant Cinchona officinalis. This metabolite has been extensively studied for its role in the metabolism of nevirapine and its possible therapeutic applications, such as its ability to inhibit HIV replication.

Formula: C₁₅H₁₂N₄O₃

Purity: Min. 95%

Molecular weight: 296.28 g/mol

Ref: 3D-VJA50102