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CAS 24589-78-4

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Description:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide, commonly referred to as MSTFA, is a chemical compound widely used in analytical chemistry, particularly in the derivatization of polar compounds for gas chromatography. It features a trifluoroacetamide functional group, which enhances the volatility and thermal stability of analytes, making them more amenable to gas chromatography analysis. The presence of the trimethylsilyl group increases the hydrophobicity of the compound, facilitating the analysis of various biomolecules, including amino acids and fatty acids. MSTFA is typically a colorless liquid with a characteristic odor and is known for its reactivity, particularly with hydroxyl and carboxyl groups, leading to the formation of stable silyl derivatives. It is important to handle MSTFA with care, as it can be irritating to the skin and respiratory system. In laboratory settings, it is often utilized in conjunction with mass spectrometry to improve detection sensitivity and specificity. Overall, MSTFA is a valuable reagent in the field of organic chemistry and analytical applications.
Formula:C6H12F3NOSi
InChI:InChI=1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
InChI key:InChIKey=MSPCIZMDDUQPGJ-UHFFFAOYSA-N
SMILES:C(N([Si](C)(C)C)C)(C(F)(F)F)=O
Synonyms:
  • 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide
  • Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-
  • Mstfa
  • N-Methyl-N-trimethylsilyltrifluoracetamide
  • N-methyl-n-trimethylsilyltrifluoroacetamide
  • NSC 339701
  • N-Methyl-N-(trimethylsilyl)trifluoroacetamide
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