FOXO4-DRI, with the CAS number 2460055-10-9, is a small molecule designed to selectively target and inhibit the FOXO4 protein, which plays a crucial role in cellular processes such as apoptosis, stress resistance, and aging. This compound has garnered attention in the field of aging research due to its potential to induce cell death in senescent cells, thereby promoting tissue regeneration and improving healthspan. FOXO4-DRI operates by disrupting the interaction between FOXO4 and p53, leading to the selective elimination of senescent cells, which are associated with various age-related diseases. The compound is typically characterized by its synthetic origin, specific molecular structure, and biological activity, making it a valuable tool in experimental studies aimed at understanding cellular senescence and developing therapeutic strategies for age-related conditions. As research continues, FOXO4-DRI may provide insights into novel approaches for enhancing longevity and combating age-associated disorders.

FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.

FOXO4-DRI

2460055-10-9: FOXO4-DRI, with the CAS number 2460055-10-9, is a small molecule designed to selectively target and inhibit the FOXO4 protein, which plays a crucial role in cellular processes such as apoptosis, stress resistance, and aging. This compound has garnered attention in the field of aging research due to its potential to induce cell death in senescent cells, thereby promoting tissue regeneration and improving healthspan. FOXO4-DRI operates by disrupting the interaction between FOXO4 and p53, leading to the selective elimination of senescent cells, which are associated with various age-related diseases. The compound is typically characterized by its synthetic origin, specific molecular structure, and biological activity, making it a valuable tool in experimental studies aimed at understanding cellular senescence and developing therapeutic strategies for age-related conditions. As research continues, FOXO4-DRI may provide insights into novel approaches for enhancing longevity and combating age-associated disorders.

<p>FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.</p>

CAS 2460055-10-9

FOXO4-DRI

FOXO4-DRI

Ref: TM-T76563