CAS 246021-20-5

9,11-Didehydroestriol

Description:

9,11-Didehydroestriol is a synthetic derivative of estriol, a naturally occurring estrogen. This compound is characterized by the presence of double bonds at the 9 and 11 positions of the steroid nucleus, which alters its biological activity compared to its parent compound. It is primarily studied for its potential therapeutic applications, particularly in hormone replacement therapy and in the treatment of certain estrogen-sensitive conditions. The molecular structure of 9,11-Didehydroestriol includes a phenolic hydroxyl group, contributing to its estrogenic properties. Its pharmacological profile may include effects on various estrogen receptors, influencing processes such as cell proliferation and differentiation. Additionally, the compound's stability, solubility, and metabolic pathways are important factors in its efficacy and safety as a therapeutic agent. As with many steroid derivatives, the synthesis and characterization of 9,11-Didehydroestriol require careful consideration of stereochemistry and purity to ensure its intended biological effects.

Formula: C₁₈H₂₂O₃

InChI: InChI=1/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5-6,8,14-17,19-21H,2,4,7,9H2,1H3/t14-,15+,16-,17+,18+/m1/s1

Synonyms:

• Estra-1,3,5,9(11)-tetraene-3,16a,17b-triol
• (16Alpha,17Beta)-Estra-1,3,5(10),9(11)-Tetraene-3,16,17-Triol

Estriol Related Compound A (Estra-1,3,5(10),9(11)-tetraene-3,16α,17β-triol)

CAS: 246021-20-5

Estrogens and progestins

Formula: C₁₈H₂₂O₃

Color and Shape: Cream Off-White Powder

Molecular weight: 286.15689

Ref: 45-1254519

Estriol EP Impurity A (Estriol USP Related Compound A)

CAS: 246021-20-5

Formula: C₁₈H₂₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 286.37

Ref: 4Z-E-352

Estriol Impurity 2 Sodium Salt

CAS: 246021-20-5

Formula: C₂₄H₃₁O₁₀·Na

Color and Shape: White To Off-White Solid

Molecular weight: 479.50 22.99

Ref: 4Z-E-3522

Estra-1,3,5(10),9(11)-tetraene-3,16α,17β-triol (9,11-Didehydroestriol)

Controlled Product

CAS: 246021-20-5

Formula: C₁₈H₂₂O₃

Color and Shape: Neat

Molecular weight: 286.37

Ref: 86-MM0130.06

9,11-Didehydrooestriol

Controlled Product

CAS: 246021-20-5

Impurity Estriol EP Impurity A
Stability Hygroscopic
Applications 9,11-Didehydrooestriol (Estriol EP Impurity A) is an impurity of Estriol (E888960), a metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).
References Marrian, et al.: Biochem. J., 23,1090 (1929), Huffman, et al.: J. Biol. Chem., 169, 167 (1947),

Formula: C₁₈H₂₂O₃

Color and Shape: Off-White

Molecular weight: 286.37

Ref: TR-D439538

9,11-Didehydroestriol

Controlled Product

CAS: 246021-20-5

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Formula: C₁₈H₂₂O₃

Purity: Min. 95%

Molecular weight: 286.37 g/mol

Ref: 3D-FD150546

Estriol EP Impurity A

CAS: 246021-20-5

Formula: C₁₈H₂₂O₃

Molecular weight: 286.4

Ref: ST-EA-CP-E28001