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CAS 246252-06-2

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Motexafin gadolinium

Description:
Motexafin gadolinium is a chemical compound that belongs to the class of gadolinium-based agents, primarily known for its applications in medical imaging and cancer therapy. It is characterized by its unique structure, which includes a gadolinium ion complexed with a chelating agent. This compound exhibits paramagnetic properties, making it useful as a contrast agent in magnetic resonance imaging (MRI). Motexafin gadolinium has been investigated for its potential to enhance the efficacy of radiation therapy in cancer treatment by selectively accumulating in tumor tissues and enhancing oxidative stress within cancer cells. Additionally, it has shown the ability to modulate cellular signaling pathways, which may contribute to its therapeutic effects. The compound is typically administered intravenously and is subject to rigorous safety evaluations due to the presence of gadolinium, which can pose risks of nephrotoxicity in patients with impaired kidney function. Overall, motexafin gadolinium represents a significant advancement in the field of oncological imaging and treatment, although its clinical use is carefully monitored.
Formula:C52H72GdN5O14
InChI:InChI=1S/C48H66N5O10.2C2H4O2.Gd/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);/q-1;;;+3/p-2/b39-27-,40-28-,41-27?,42-28?,45-31-,46-32-,49-31?,49-43+,50-32?,50-44+;;;
InChI key:InChIKey=VAZLWPAHMORDGR-WWENWXKTSA-L
SMILES:[O-](C(C)=O)[Gd+3]1234([O-]C(C)=O)[N-]5C=6C=C7[N]1=C(C=[N]2C=8C([N]3=CC9=[N]4C(=CC5=C(CC)C6CC)C(CCCO)=C9C)=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C8)C(C)=C7CCCO
Synonyms:
  • (PB-7-11-233′2′4)-Bis(acetato-κO)[9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-κN1,κN18,κN23,κN24,κN25]gadolinium
  • Xcytrin
  • Gadolinium texaphyrin
  • Gadolinium, bis(acetato-κO)[9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-κN1,κN18,κN23,κN24,κN25]-, (PB-7-11-233′2′4)-
  • Motexafin gadolinium
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