CAS 246529-22-6

Aramchol

Description:

Aramchol, with the CAS number 246529-22-6, is a synthetic compound that belongs to the class of fatty acid derivatives. It is primarily recognized for its role as a modulator of the endocannabinoid system, specifically acting as a selective agonist of the cannabinoid receptor type 2 (CB2). Aramchol has garnered attention for its potential therapeutic applications, particularly in the treatment of metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and obesity. The compound exhibits properties that may help in reducing liver fat accumulation and improving metabolic parameters. In terms of its chemical structure, Aramchol is characterized by a long-chain fatty acid moiety, which contributes to its biological activity. Its pharmacokinetic profile and safety profile are subjects of ongoing research, as it is being evaluated in clinical trials. Overall, Aramchol represents a promising avenue in the development of treatments targeting metabolic diseases, leveraging its unique interaction with the endocannabinoid system.

Formula: C₄₄H₇₉NO₅

InChI: InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1

InChI key: InChIKey=SHKXZIQNFMOPBS-OOMQYRRCSA-N

SMILES: O[C@H]1[C@@]2([C@@]([C@]3(C)[C@](C1)(C[C@@H](NC(CCCCCCCCCCCCCCCCCCC)=O)CC3)[H])(C[C@H](O)[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])[H])[H]

Synonyms:

• (3β)-Arachidylamido-7α,12α-dihydroxy-5β-cholan-24-oic acid
• (3β,5β,7α,12α)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid
• (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• C₂₀-FABAC
• Cholan-24-oic acid, 7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-, (3β,5β,7α,12α)-
• C20-FABAC
• Aramchol
• (3beta)-Arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid
• Aramchol (in progress)
• (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoicacid
• (3beta,5beta,7alpha,12alpha)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid

Aramchol

CAS: 246529-22-6

Aramchol

Purity: ≥95%

Molecular weight: 702.1g/mol

Ref: 54-BUP05809

Aramchol

CAS: 246529-22-6

Formula: C₄₄H₇₉NO₅

Molecular weight: 702.12

Ref: 4Z-A-298001

Aramchol-d39

CAS: 246529-22-6

Formula: C₄₄H₄₀D₃₉NO₅

Molecular weight: 741.36

Ref: 4Z-A-298004

Aramchol

CAS: 246529-22-6

Aramchol (C20-FABAC), a mix of arachidic & cholic acid, lessens cholesterol crystallization & dissolves crystals in bile.

Formula: C₄₄H₇₉NO₅

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 702.1

Ref: TM-T7294

Aramchol

Controlled Product

CAS: 246529-22-6

Applications Aramchol is a fatty acid conjugate that exhibits hypocholesterolemic effects. Studies have shown that aramchol suppresses the activity of stearoyl-CoA desaturase (SCD), which leads to reduction of obesity, fatty liver and insulin resistance.
References Leikin-Frenkel, A., et al.: Arch Med Res. 41, 397 (2010); Gonen, A., et al.: Pathobiology 70, 215 (2003)

Formula: C₄₄H₇₉NO₅

Color and Shape: Neat

Molecular weight: 702.1

Ref: TR-A765150

Aramchol

CAS: 246529-22-6

Formula: C₄₄H₇₉NO₅

Molecular weight: 702.12

Ref: ST-EA-CP-A275000