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CAS 24668-75-5

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Dexamethasone tert-butylacetate

Description:
Dexamethasone tert-butylacetate is a synthetic corticosteroid derivative, primarily used for its anti-inflammatory and immunosuppressive properties. It is a prodrug of dexamethasone, meaning it is converted into the active form in the body. The compound features a tert-butyl acetate moiety, which enhances its lipophilicity, potentially improving its absorption and bioavailability. Dexamethasone itself is known for its potent glucocorticoid activity, making this derivative useful in various therapeutic applications, including the treatment of conditions such as allergies, autoimmune disorders, and certain types of cancer. The chemical structure includes a steroid backbone with specific functional groups that contribute to its pharmacological effects. Dexamethasone tert-butylacetate is typically administered via injection or orally, depending on the clinical context. As with other corticosteroids, it may have side effects, including potential impacts on metabolism, immune response, and electrolyte balance, necessitating careful monitoring during treatment. Overall, this compound exemplifies the modifications made to enhance the therapeutic efficacy of corticosteroids in clinical practice.
Formula:C28H39FO6
InChI:InChI=1/C28H39FO6/c1-16-11-20-19-8-7-17-12-18(30)9-10-25(17,5)27(19,29)21(31)13-26(20,6)28(16,34)22(32)15-35-23(33)14-24(2,3)4/h9-10,12,16,19-21,31,34H,7-8,11,13-15H2,1-6H3/t16-,19+,20+,21+,25+,26+,27+,28+/m1/s1
InChI key:InChIKey=PQVDYPCHUGFHAR-PKWREOPISA-N
SMILES:C[C@@]12[C@]([C@]3([C@](F)([C@@H](O)C1)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])(C[C@@H](C)[C@@]2(C(COC(CC(C)(C)C)=O)=O)O)[H]
Synonyms:
  • (11β,16α)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 3,3-Dimethylbutanoate
  • Butyric acid, 3,3-dimethyl-, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • Decadron TBA
  • Dexamethasone tert-butylacetate
  • Dexamethasone-21-tert-butylacetate
  • Pregna-1,4-diene-3,20-dione, 21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(3,3-dimethylbutyrate)
  • DEXAMETHASONE-T-BUTYLACETATE
  • Dexamethason 21-tert-butylacetat
  • See more synonyms
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