CAS 246852-12-0

Amlodipine mesylate

Description:

Amlodipine mesylate is a pharmaceutical compound primarily used as an antihypertensive agent in the treatment of high blood pressure and angina. It is a salt form of amlodipine, which is a dihydropyridine calcium channel blocker. The mesylate (methanesulfonate) salt enhances the solubility and stability of the drug, facilitating its absorption in the body. Amlodipine mesylate is characterized by its ability to selectively inhibit calcium influx into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced peripheral resistance. This results in lowered blood pressure and improved blood flow. The compound is typically administered orally and is known for its long half-life, allowing for once-daily dosing. In terms of physical properties, amlodipine mesylate is generally a white to off-white crystalline powder, soluble in water and methanol, and has a specific melting point range. Its safety profile is well-established, with common side effects including headache, edema, and fatigue. Overall, amlodipine mesylate is an effective and widely used medication in cardiovascular therapy.

Formula: C₂₀H₂₅ClN₂O₅·CH₄O₃S

InChI: InChI=1S/C20H25ClN2O5.CH4O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;1-5(2,3)4/h5-8,17,23H,4,9-11,22H2,1-3H3;1H3,(H,2,3,4)

InChI key: InChIKey=MUVFCHUBATVFPP-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2.S(C)(=O)(=O)O

Synonyms:

• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester methanesulfonate (1:1)
• 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monomethanesulfonate
• Amlodipine mesylate

3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; methanesulfonic acid

CAS: 246852-12-0

Formula: C₂₁H₂₉ClN₂O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 504.9816

Ref: IN-DA007MJK

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate

CAS: 246852-12-0

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate

Purity: 98%

Molecular weight: 504.98g/mol

Ref: 54-OR1042832

Amlodipine Mesilate

Controlled Product

CAS: 246852-12-0, 88150-42-9

Formula: C₂₀H₂₅ClN₂O₅

Color and Shape: Neat

Molecular weight: 408.88

Ref: 86-MM0592.00

Amlodipine mesylate

CAS: 246852-12-0

Amlodipine mesylate, an oral dihydropyridine Ca2+ blocker, treats angina, hypertension, and may be used in cancer research.

Formula: C₂₁H₂₉ClN₂O₈S

Color and Shape: Solid

Molecular weight: 504.98

Ref: TM-T63445

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate

CAS: 246852-12-0

Amlodipine is a calcium channel blocker that reduces the frequency of heartbeat and lowers blood pressure. It is used to treat high blood pressure, chest pain caused by primary pulmonary hypertension, and Raynaud's phenomenon. Amlodipine is a particle that has been coated with a human serum protein (albumin) to make it more stable in the human body. This drug can be taken orally or intravenously. Side effects may include headache, dizziness, or swelling in hands or feet.

Formula: C₂₁H₂₉ClN₂O₈S

Purity: Min. 95%

Molecular weight: 504.98 g/mol

Ref: 3D-WJA85212