CAS 246870-46-2

Cetirizine Ethyl Ester

Description:

Cetirizine Ethyl Ester, with the CAS number 246870-46-2, is a chemical compound derived from cetirizine, an antihistamine commonly used to treat allergic symptoms. This compound is characterized by its ethyl ester functional group, which influences its solubility and pharmacokinetic properties. Cetirizine Ethyl Ester is typically a white to off-white solid, exhibiting low solubility in water but higher solubility in organic solvents. It is known for its antihistaminic activity, which helps alleviate symptoms such as sneezing, runny nose, and itching associated with allergies. The compound is also recognized for its relatively low sedative effects compared to first-generation antihistamines, making it suitable for long-term use. Its mechanism of action involves selective antagonism of peripheral H1 receptors, thereby inhibiting the effects of histamine. Additionally, the ethyl ester modification may enhance its bioavailability and therapeutic efficacy. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by appropriate medical advice.

Synonyms:

• Ethyl 2-[2-[4-[(4-Chlorophenyl)-Phenylmethyl]Piperazin-1-Yl]Ethoxy]Acetate
• Ace086
• Ethyl (2-{4-[(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetate

Cetirizine Related Compound A ((RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid ethyl ester oxalate)

CAS: 246870-46-2

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, nesoi

Formula: C₂₅H₃₁ClN₂O₇

Color and Shape: White Powder

Molecular weight: 506.98

Ref: 45-1102930

Cetirizine USP Related Compound A DiHCl

CAS: 246870-46-2

Formula: C₂₃H₂₉ClN₂O₃·2HCl

Color and Shape: Pale Brown Solid

Molecular weight: 416.95 2*36.46

Ref: 4Z-C-2036

Cetirizine Ethyl Ester

CAS: 246870-46-2

Applications Cetirizine Ethyl Ester, is an intermediate for the preparation of Cetirizine (C281100), which is a nonsedating type histamine H1-receptor antagonist. It is an antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. It is a major metabolite of Hydroxyzine (H996500).
References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987), Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987), Fadel, R., et al.: Clin. Allergy, 17, 373 (1987), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

Formula: C₂₃H₂₉ClN₂O₃

Color and Shape: Neat

Molecular weight: 416.941

Ref: TR-C291145

Cetirizine Related Compound A

CAS: 246870-46-2

Cetirizine Related Compound A is a synthetic compound that belongs to the group of medicines. It is a drug substance that is used in the production of Cetirizine, which is an antihistamine with H1-receptor antagonist activity. Cetirizine Related Compound A can be synthesized by reacting metformin with an aldimine, such as 1-oxa-2,4-diaminobenzene. The synthesis process requires organometallic reagents and the use of catalysts, such as palladium on carbon or platinum oxide. Impurities may be formed during the synthesis process and include cetirizine, N-formylcetirizine, and other impurities. These impurities are identified according to their profile and profiles, which are determined by analytical methods such as gas chromatography (GC) or high performance liquid chromatography (HPLC).

Formula: C₂₃H₂₉ClN₂O₃·2HCl

Purity: Min. 95%

Molecular weight: 489.86 g/mol

Ref: 3D-WJA87046

Levocetirizine USP Related compound A

CAS: 246870-46-2

Formula: C₂₃H₂₉ClN₂O₃

Molecular weight: 416.95

Ref: ST-EA-CP-L15008

Cetirizine USP Related Compound A

CAS: 246870-46-2

Formula: C₂₃H₂₉ClN₂O₃

Molecular weight: 416.94

Ref: ST-EA-CP-C14008