CAS 247068-82-2

1,1-Dimethylethyl N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamate

Description:

1,1-Dimethylethyl N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamate, with CAS number 247068-82-2, is a chemical compound characterized by its complex structure, which includes a carbamate functional group and an epoxide moiety. This compound features a branched alkyl chain, contributing to its steric hindrance and potentially influencing its reactivity and solubility. The presence of the epoxide ring suggests that it may participate in nucleophilic reactions, making it a candidate for various synthetic applications. Additionally, the stereochemistry indicated by the (1S) and (2R) designations implies that the compound exhibits chirality, which can affect its biological activity and interactions with other molecules. The overall molecular structure suggests potential uses in pharmaceuticals or agrochemicals, where specific interactions with biological systems are crucial. However, detailed studies on its physical properties, such as melting point, boiling point, and solubility, would be necessary to fully understand its behavior in different environments.

Formula: C₁₄H₂₅NO₄

InChI: InChI=1S/C14H25NO4/c1-9(2)7-10(11(16)14(6)8-18-14)15-12(17)19-13(3,4)5/h9-10H,7-8H2,1-6H3,(H,15,17)/t10-,14+/m0/s1

InChI key: InChIKey=DDMPMIMTLBGEHT-IINYFYTJSA-N

SMILES: C([C@@H](NC(OC(C)(C)C)=O)CC(C)C)(=O)[C@@]1(C)CO1

Synonyms:

• (2R)-2-[(2S)-2-(tert-Butoxycarbonylamino)-4-methylpentanoyl]-2-methyloxirane
• 1,1-Dimethylethyl N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamate
• Boc-L-leucine epoxyketone
• Boc-Leucine-epoxylketone
• Carbamic acid, N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester
• Carbamic acid, [(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester
• Carfilzomib intermediate 1
• Tert-Butyl 4-Methyl-1-(2-Methyloxiran-2-Yl)-1-Oxopentan-2-Ylcarbamate
• Tert-butyl N-[(2s)-4-methyl-1-[(2r)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate
• [3-Methyl-1-(2-methyl-oxiranecarbonyl)-butyl]-carbamic acid tert-butyl ester
• tert-butyl (S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamate

CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester

CAS: 247068-82-2

Formula: C₁₄H₂₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 271.3526

Ref: IN-DA002P3R

Tert-Butyl ((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Carbamate

CAS: 247068-82-2

Tert-Butyl ((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Carbamate

Purity: 98%

Molecular weight: 271.35g/mol

Ref: 54-OR1029417

(2S)-2-(Boc-amino)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentane ee

CAS: 247068-82-2

Versatile small molecule scaffold

Formula: C₁₄H₂₅NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 271.35 g/mol

Ref: 3D-XJA06882

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

CAS: 247068-82-2

Formula: C₁₄H₂₅NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 271.357

Ref: 10-F497427

tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

Controlled Product

CAS: 247068-82-2

Applications tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Wang, P., et al.: Process for preparation of carfilzomib, China Patent 2015010436, Jan 29, 2015; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)

Formula: C₁₄H₂₅NO₄

Color and Shape: Neat

Molecular weight: 271.35

Ref: TR-B809210

Carfilzomib Impurity 23

CAS: 247068-82-2

Formula: C₁₄H₂₅NO₄

Molecular weight: 271.36

Ref: ST-EA-CP-C153025

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

CAS: 247068-82-2

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

Formula: C₁₄H₂₅NO₄

Color and Shape: Solid

Molecular weight: 271.357

Ref: TM-T66629