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CAS 247257-48-3

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Fimasartan

Description:
Fimasartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. Fimasartan is characterized by its selective inhibition of the AT1 receptor, which contributes to its antihypertensive effects. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. In terms of its chemical structure, Fimasartan features a unique molecular framework that includes a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological properties. It is generally well-tolerated, with a side effect profile similar to other medications in its class, including dizziness, fatigue, and potential renal effects. As with any medication, it is essential to use Fimasartan under medical supervision, considering potential interactions with other drugs and individual patient health conditions.
Formula:C27H31N7OS
InChI:InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)
InChI key:InChIKey=AMEROGPZOLAFBN-UHFFFAOYSA-N
SMILES:C(C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1)N4C(CCCC)=NC(C)=C(CC(N(C)C)=S)C4=O
Synonyms:
  • 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-5-pyrimidineethanethioamide
  • 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
  • 2-[2-Butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
  • 2-n-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
  • 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
  • 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
  • Kanarb
  • Fimasartan
  • 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP
  • 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide
  • See more synonyms
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