CAS 247257-48-3

Fimasartan

Description:

Fimasartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. Fimasartan is characterized by its selective inhibition of the AT1 receptor, which contributes to its antihypertensive effects. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. In terms of its chemical structure, Fimasartan features a unique molecular framework that includes a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological properties. It is generally well-tolerated, with a side effect profile similar to other medications in its class, including dizziness, fatigue, and potential renal effects. As with any medication, it is essential to use Fimasartan under medical supervision, considering potential interactions with other drugs and individual patient health conditions.

Formula: C₂₇H₃₁N₇OS

InChI: InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)

InChI key: InChIKey=AMEROGPZOLAFBN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1)N4C(CCCC)=NC(C)=C(CC(N(C)C)=S)C4=O

Synonyms:

• 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-5-pyrimidineethanethioamide
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 2-[2-Butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
• 2-n-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• Kanarb
• Fimasartan
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP
• 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim
• BR-A-657
• 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
• KANARB; BR-A-657
• Fimasartan(BR-A-657)
• Unii-p58222188p
• 2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide
• FiMasartan USP/EP/BP

5-​Pyrimidineethanethio​amide, 2-​butyl-​1,​6-​dihydro-​N,​N,​4-​trimethyl-​6-​oxo-​1-​[[2'-​(2H-​tetrazol-​5-​yl)​[1,​1'-​biphenyl]​-​4-​yl]​methyl]​-

CAS: 247257-48-3

Formula: C₂₇H₃₁N₇OS

Purity: 97%

Color and Shape: Solid

Molecular weight: 501.6463

Ref: IN-DA002P8I

Fimasartan

CAS: 247257-48-3

Fimasartan

Purity: ≥95%

Molecular weight: 501.65g/mol

Ref: 54-BUP06317

Fimasartan-d6

CAS: 247257-48-3

Formula: C₂₇H₂₅D₆N₇OS

Color and Shape: White To Off-White Solid

Molecular weight: 507.69

Ref: 4Z-F-492

Fimasartan

CAS: 247257-48-3

Formula: C₂₇H₃₁N₇OS

Color and Shape: White To Off-White Solid

Molecular weight: 501.65

Ref: 4Z-F-491

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

CAS: 247257-48-3

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

Purity: 99%

Molecular weight: 501.65g/mol

Ref: 54-OR1025664

Fimasartan

CAS: 247257-48-3

Fimasartan (BR-A-657), an ARB, treats hypertension and heart failure; safe with hydrochlorothiazide.

Formula: C₂₇H₃₁N₇OS

Purity: 98.96%

Color and Shape: Solid

Molecular weight: 501.65

Ref: TM-T2322

Fimasartan

Controlled Product

CAS: 247257-48-3

Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.
References Lee, H., et al.: Drugs, 76, 1015 (2016)

Formula: C₂₇H₃₁N₇OS

Color and Shape: Neat

Molecular weight: 501.65

Ref: TR-F342040

Fimasartan

CAS: 247257-48-3

Angiotensin II receptor antagonist

Formula: C₂₇H₃₁N₇OS

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 501.65 g/mol

Ref: 3D-FB75008