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CAS 24729-96-2

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Clindamycin phosphate

Description:
Clindamycin phosphate is a semi-synthetic antibiotic derived from lincomycin, primarily used to treat various bacterial infections, particularly those caused by anaerobic bacteria and certain gram-positive organisms. It is characterized by its phosphate ester form, which enhances its solubility and stability in aqueous solutions, making it suitable for parenteral and topical formulations. Clindamycin phosphate exhibits a mechanism of action by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, effectively disrupting the growth of susceptible bacteria. The compound is often utilized in the treatment of skin infections, respiratory tract infections, and certain types of bone infections. It is important to note that clindamycin phosphate can cause side effects, including gastrointestinal disturbances and the risk of Clostridium difficile-associated diarrhea. As with any antibiotic, appropriate use is crucial to minimize the development of resistance. The substance is typically administered in various forms, including gels, creams, and injectable solutions, depending on the specific clinical indication.
Formula:C18H34ClN2O8PS
InChI:InChI=1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1
InChI key:InChIKey=UFUVLHLTWXBHGZ-MGZQPHGTSA-N
SMILES:[C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@H](C)Cl)[C@]2(O[C@H](SC)[C@H](OP(=O)(O)O)[C@@H](O)[C@H]2O)[H]
Synonyms:
  • 7(S)-Chloro-7-deoxylincomycin 2-phosphate
  • <span class="text-smallcaps">L</smallcap>-threo-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α-
  • <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-
  • <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate)
  • Cleocin T
  • Cleocin phosphate
  • Clinadac
  • Clindac
  • Clindagel
  • Clindamycin 2-phosphate
  • See more synonyms
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Found 18 products.