CAS 24730-10-7

Dihydroergocristine Mesylate

Description:

Dihydroergocristine mesylate is a semi-synthetic derivative of ergot alkaloids, primarily used in pharmacological applications. It is characterized by its ability to act as a vasodilator and has been studied for its potential neuroprotective effects. The compound is typically presented as a mesylate salt, which enhances its solubility and stability in various formulations. Dihydroergocristine mesylate exhibits a complex structure, featuring multiple chiral centers, which contributes to its biological activity. It is known to interact with adrenergic and serotonergic receptors, influencing neurotransmitter release and vascular tone. The substance is often utilized in the treatment of conditions such as peripheral vascular disorders and cognitive decline associated with aging. Safety and efficacy profiles are established through clinical studies, although side effects may include gastrointestinal disturbances and cardiovascular effects. As with many pharmacological agents, its use should be monitored by healthcare professionals to mitigate potential adverse reactions.

Formula: C₃₆H₄₅N₅O₈S

InChI: InChI=1/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1

InChI key: InChIKey=SPXACGZWWVIDGR-SPZWACKZSA-N

SMILES: O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@@H]5C[C@@]6(C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)[H])(C(C)C)O2.S(C)(=O)(=O)O

Synonyms:

• (5'Alpha,10Alpha)-5'-Benzyl-12'-Hydroxy-3',6',18-Trioxo-2'-(Propan-2-Yl)-9,10-Dihydroergotaman Methanesulfonate (1:1)
• 5'alpha-Benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
• 9,10-Dihydroergocristine methanesulfonate
• Dihydroergocristine methanesulfonate
• Dihydroergocristinmesilat
• Dihydroergocristinmesilat [German]
• Ergocristine, 9,10-dihydro-, monomethanesulfonate (salt)
• Ergocristine, dihydro-, methanesulfonate
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, monomethanesulfonate (salt)
• Ergotamane-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'-alpha,10-alpha)-, monomethanesulfonate (salt)
• GNF Pf 3462
• Unii-Ds7Cl18Uam
• Dihydroergocristine mesylate
• DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID, VASOC
• ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
• (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
• (5,10a)-9,10-Dihydro-12hydroxy-2(1-methylethyl)-5(phenylmethyl)-ergotamane-3618-trionemesylate]
• (5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate
• DIHYDROERGOCRYSTINE METHANESULFONATE SALT
• Dihydroergocristine mesilate (D1945000)
• (5'A,10A)-9,10-DIHYDRO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(PHENYLMETHYL)-ERGOTAMAN-3',6',18-TRIONE MESYLATE
• Dihydroergocristine mesilate CRS
• 9,10-dihydro-ergocristinmonomethanesulfonate(salt)
• (5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt)
• dihydroergocristine methanesulfonate salt
• C13168
• Dihydroergotamine Mesilate Impurity E as Mesilate
• Dihydroergotamine Mesilate EP Impurity E as Mesilate

Dihydroergocristine methanesulfonate

CAS: 24730-10-7

5-HT receptor antagonist; partial agonist at adrenergic and dopaminergic receptors

Formula: C₃₆H₄₅N₅O₈S

Color and Shape: White, Powder or crystals or crystalline powder

Molecular weight: 707.84

Ref: 02-J60638

DIHYDROERGOCRISTINE MESILATE CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE CRS

Formula: C₃₆H₄₅N₅O₈S

Molecular weight: 707.8362

Ref: 41-D1945000

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

Ref: 41-Y0002323

Dihydroergocristine (mesylate)

CAS: 24730-10-7

Formula: C₃₆H₄₅N₅O₈S

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 707.8362

Ref: IN-DA002P9C

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine mesylate

Purity: ≥98%

Molecular weight: 707.84g/mol

Ref: 54-BUP12047

Dihydroergocristine Mesilate

Controlled Product

CAS: 24730-10-7

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Color and Shape: Neat

Molecular weight: 707.84

Ref: 86-MM1812.00

Dihydroergocristine mesylate

CAS: 24730-10-7

DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.

Formula: C₃₆H₄₅N₅O₈S

Purity: 98.9% - 99.65%

Color and Shape: Solid

Molecular weight: 707.84

Ref: TM-T11043

9,10-Dihydroergocristine Methanesulfonate

CAS: 24730-10-7

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Molecular weight: 611.74 96.10

Ref: 4Z-E-088005

Dihydroergocristine Mesylate

CAS: 24730-10-7

Dihydroergocristine Mesylate

Molecular weight: 707.84g/mol

Ref: 54-BID1021

9,10-Dihydroergocristine Methanesulfonate

Controlled Product

CAS: 24730-10-7

Applications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.
References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Color and Shape: Neat

Molecular weight: 707.84

Ref: TR-D446440

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine is an anti-hypertensive drug that belongs to the class of pharmacological agents. It is used for the treatment of high blood pressure and has been shown to reduce the risk of stroke in patients with cerebrovascular disease. Dihydroergocristine has been found to inhibit the production of 5-hydroxytryptamine (5-HT) by binding to serotonin receptors in vitro, although its effects on human serum levels have not been determined. This drug also inhibits certain enzymes, such as energy metabolism and protein synthesis. Dihydroergocristine can be administered in a solution or as an injection, depending on the severity of symptoms.

Formula: C₃₆H₄₅N₅O₈S

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 707.84 g/mol

Ref: 3D-FD39334

Dihydroergocristine mesilate

CAS: 24730-10-7

Dihydroergocristine mesilate

Color and Shape: White Solid

Ref: 47-120