CAS 2477-73-8

(6α)-17-(Acetyloxy)-6-chloropregn-4-ene-3,20-dione

Description:

The chemical substance known as (6α)-17-(Acetyloxy)-6-chloropregn-4-ene-3,20-dione, with the CAS number 2477-73-8, is a synthetic steroid compound that belongs to the class of progestins. It features a chlorinated structure, which contributes to its biological activity. The presence of an acetoxy group at the 17-position enhances its lipophilicity, potentially influencing its absorption and distribution in biological systems. This compound exhibits progestational activity, making it relevant in the field of reproductive health and hormonal therapies. Its structural characteristics include a pregnane backbone, which is typical of steroid hormones, and specific functional groups that modulate its interaction with hormone receptors. The compound is primarily studied for its pharmacological properties and potential applications in contraceptive formulations or hormone replacement therapies. As with many synthetic steroids, its safety profile, efficacy, and mechanism of action are subjects of ongoing research in medicinal chemistry and pharmacology.

Formula: C₂₃H₃₁ClO₄

InChI: InChI=1S/C23H31ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11,16-18,20H,5-10,12H2,1-4H3/t16-,17+,18+,20+,21-,22+,23+/m1/s1

InChI key: InChIKey=DCVGANSDLNPXGO-WXLIAARGSA-N

SMILES: O(C(C)=O)[C@@]1(C(C)=O)[C@]2(C)[C@@](CC1)([C@]3([C@](CC2)([C@]4(C)C([C@@H](Cl)C3)=CC(=O)CC4)[H])[H])[H]

Synonyms:

• (6α)-17-(Acetyloxy)-6-chloropregn-4-ene-3,20-dione
• 17-Acetoxy-6α-chloropregn-4-ene-3,20-dione
• 6.alpha.-Chloro-17-acetoxyprogesterone
• 6.alpha.-Chloro-17-hydroxyprogesterone acetate
• 6alpha-Chloro-17-hydroxypregn-4-ene-3,20-dione acetate
• 6α-Chloro-17-acetoxyprogesterone
• 6α-Chloro-17-hydroxyprogesterone acetate
• Hydromadinone acetate
• NSC 33170
• Pregn-4-Ene-3,20-Dione, 17-(Acetyloxy)-6-Chloro-, (6Alpha)-
• Pregn-4-ene-3,20-dione, 17- (acetyloxy)-6-chloro-, (6.alpha.)-
• Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-chloro-, (6α)-
• Pregn-4-ene-3,20-dione, 6alpha-chloro-17-hydroxy-, acetate (8CI)
• Pregn-4-ene-3,20-dione, 6α-chloro-17-hydroxy-, acetate
• Progesterone, 6.alpha.-chloro-17-hydroxy-, acetate
• Progesterone, 6α-chloro-17-hydroxy-, acetate

Progesterone Impurity 17

CAS: 2477-73-8

Formula: C₂₃H₃₁ClO₄

Molecular weight: 406.95

Ref: 4Z-P-3266

6α-Chloro-17-acetoxy progesterone

Controlled Product

CAS: 2477-73-8

6alpha-Chloro-17-acetoxy progesterone is a synthetic, nonsteroidal estrogen. It is a potent inhibitor of the proliferation of human breast cancer cells in vitro and in vivo. Progesterone has been shown to inhibit the growth rate of human breast cancer cells by blocking the cell cycle at G2/M phase, with no effect on DNA synthesis or mitosis. The parameters for monitoring the growth rates are average rates, transport rates, and overlapped rates. The average growth rate is calculated as the proportionality between the number of events and time intervals. Transport rates are expressed as the ratio between an event type and time intervals. Overlapped rates are expressed as the ratio between two types of events that occur during overlapping time intervals. 6alpha-Chloro-17-acetoxy progesterone has been envisaged to be used as a treatment for hormone receptor positive breast cancer patients who have failed initial endocrine therapy and are not candidates for chemotherapy due

Formula: C₂₃H₃₁ClO₄

Purity: Min. 95%

Molecular weight: 406.94 g/mol

Ref: 3D-IC19976

Chlormadinone Acetate EP Impurity A

CAS: 2477-73-8

Formula: C₂₃H₃₁ClO₄

Molecular weight: 406.94

Ref: ST-EA-CP-C68001

Progesterone Impurity 17

CAS: 2477-73-8

Formula: C₂₃H₃₁ClO₄

Molecular weight: 406.95

Ref: ST-EA-CP-P133099