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CAS 247925-28-6

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N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt

Description:
N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt, commonly referred to as DSPE-PEG, is a phospholipid derivative that features a polyethylene glycol (PEG) moiety. This compound is characterized by its amphiphilic nature, possessing both hydrophilic (PEG) and hydrophobic (stearoyl chains) components, which facilitates its use in drug delivery systems and nanocarrier formulations. The presence of the carbonyl group enhances its reactivity and stability, making it suitable for conjugation with various therapeutic agents. DSPE-PEG is known for its biocompatibility and ability to improve the solubility and circulation time of encapsulated drugs in biological systems. Additionally, the sodium salt form enhances its solubility in aqueous environments, which is advantageous for pharmaceutical applications. Overall, this compound plays a crucial role in the development of liposomal formulations and targeted drug delivery systems, contributing to advancements in therapeutic efficacy and reduced side effects.
Formula:(C2H4O)nC43H84NO10P·Na
InChI:InChI=1S/C45H88NO11P/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-43(47)54-40-42(41-56-58(50,51)55-37-36-46-45(49)53-39-38-52-3)57-44(48)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h42H,4-41H2,1-3H3,(H,46,49)(H,50,51)
InChI key:InChIKey=ULSDQCPIMGVPAF-UHFFFAOYSA-N
SMILES:C(COP(OCCNC(OCCOC)=O)(=O)O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na]
Synonyms:
  • Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, monosodium salt
  • 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol) monosodium salt
  • MPEG 2000 DSPE
  • Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, sodium salt (1:1)
  • N-(Carbonyl-methoxypolyethylene glycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt
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