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CAS 2479290-65-6

:

Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]phenyl]-3-(trifluoromethyl)-

Description:
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]phenyl]-3-(trifluoromethyl)-, identified by CAS number 2479290-65-6, is a complex organic compound characterized by its multi-functional structure. It features a benzamide core, which is a derivative of benzoic acid, where the amine group is substituted with various functional groups, including a piperazine moiety and a trifluoromethyl group. The presence of the pyrrolopyridine and pyrazole rings contributes to its potential biological activity, making it of interest in medicinal chemistry. The trifluoromethyl group enhances lipophilicity and may influence the compound's pharmacokinetic properties. This compound is likely to exhibit specific interactions with biological targets, which could be relevant for therapeutic applications. Its synthesis and characterization would involve standard organic chemistry techniques, and its stability, solubility, and reactivity would depend on the specific functional groups present in its structure.
Formula:C31H30F3N7O
Synonyms:
  • Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]phenyl]-3-(trifluoromethyl)-
  • CHMFL-48
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  • CHMFL-48
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    CHMFL-48

    CAS:
    <p>CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).</p>
    Formula:C31H30F3N7O
    Color and Shape:Solid
    Molecular weight:573.61

    Ref: TM-T89947

    10mg
    Discontinued
    50mg
    Discontinued
    Discontinued product