Immunoglobulin G1 (IgG1) is a type of antibody that plays a crucial role in the immune response by recognizing and binding to specific antigens. The substance in question, a monoclonal antibody targeting the human receptor tyrosine kinase Ror-1, is engineered from both human and Mus musculus (mouse) sources, indicating its hybrid nature. This dimeric form consists of two chains: a γ1 heavy chain and a κ light chain, linked by disulfide bonds, which are essential for maintaining the structural integrity and functionality of the antibody. The specificity of this antibody for Ror-1 suggests its potential application in therapeutic contexts, particularly in targeting certain cancers where Ror-1 is overexpressed. The dimeric structure enhances its stability and binding affinity, making it a valuable tool in both research and clinical settings. Overall, this monoclonal antibody exemplifies the advancements in biopharmaceuticals, combining elements from different species to create targeted therapies.

Immunoglobulin G1, anti-(human receptor tyrosine kinase Ror-1) (human-Mus musculus monoclonal UC-961 γ1-chain), disulfide with human-Mus musculus monoclonal UC-961 κ-chain, dimer

2485779-13-1: Immunoglobulin G1 (IgG1) is a type of antibody that plays a crucial role in the immune response by recognizing and binding to specific antigens. The substance in question, a monoclonal antibody targeting the human receptor tyrosine kinase Ror-1, is engineered from both human and Mus musculus (mouse) sources, indicating its hybrid nature. This dimeric form consists of two chains: a γ1 heavy chain and a κ light chain, linked by disulfide bonds, which are essential for maintaining the structural integrity and functionality of the antibody. The specificity of this antibody for Ror-1 suggests its potential application in therapeutic contexts, particularly in targeting certain cancers where Ror-1 is overexpressed. The dimeric structure enhances its stability and binding affinity, making it a valuable tool in both research and clinical settings. Overall, this monoclonal antibody exemplifies the advancements in biopharmaceuticals, combining elements from different species to create targeted therapies.

Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity

CAS 2485779-13-1

Immunoglobulin G1, anti-(human receptor tyrosine kinase Ror-1) (human-Mus musculus monoclonal UC-961 γ1-chain), disulfide with human-Mus musculus monoclonal UC-961 κ-chain, dimer

Zilovertamab

Ref: TM-T76749

Zilovertamab

Ref: 3D-CLA1669