CAS 24880-43-1

Mesembrine

Description:

Mesembrine is an alkaloid primarily derived from the plant *Sceletium tortuosum*, commonly known as Kanna. It is known for its psychoactive properties and has been traditionally used in South African herbal medicine for its mood-enhancing effects. Mesembrine acts as a selective serotonin reuptake inhibitor (SSRI), which may contribute to its potential antidepressant and anxiolytic effects. The compound has a complex structure, featuring a bicyclic framework that contributes to its biological activity. Mesembrine is typically found in the form of a white to off-white powder and is soluble in organic solvents but has limited solubility in water. Its pharmacological profile suggests potential applications in treating mood disorders, although further research is necessary to fully understand its efficacy and safety. As with any psychoactive substance, caution is advised regarding its use, particularly concerning dosage and potential interactions with other medications.

Formula: C₁₇H₂₃NO₃

InChI: InChI=1/C17H23NO3/c1-18-9-8-17(7-6-13(19)11-16(17)18)12-4-5-14(20-2)15(10-12)21-3/h4-5,10,16H,6-9,11H2,1-3H3/t16-,17-/m0/s1

InChI key: InChIKey=DAHIQPJTGIHDGO-IRXDYDNUSA-N

SMILES: CN1[C@@]2([C@](CC1)(CCC(=O)C2)C3=CC(OC)=C(OC)C=C3)[H]

Synonyms:

• (-)-Mesembranone
• (-)-Mesembrine
• (3aS,7aS)-3a-(3,4-Dimethoxyphenyl)octahydro-1-methyl-6H-indol-6-one
• (3aS-cis)-3a-(3,4-Dimethoxyphenyl)octahydro-1-methyl-6H-indol-6-one
• 4α,9α-Mesembrine
• 6H-Indol-6-one, 3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aS-cis)-
• 6H-indol-6-one, 3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-, (3aS,7aS)-
• Mesembrin
• (3aS,7aS)-3a-(3,4-Dimethoxyphenyl)-1-methyloctahydro-6H-indol-6-one
• (3aS,7aβ)-1-Methyl-3aβ-(3,4-dimethoxyphenyl)octahydro-6H-indole-6-one
• [3aS,7aβ,(-)]-3a-(3,4-Dimethoxyphenyl)octahydro-1-methyl-6H-indole-6-one
• Methyl-6H-Indol-6-one
• (3aS-cis)-3a-(3,4-DiMethoxyphenyl)octahydro-1-
• ( ) Mesembrine,()Mesembrine

Mesembrine

CAS: 24880-43-1

Formula: C₁₇H₂₃NO₃

Molecular weight: 289.38

Ref: 4Z-M-147008

Mesembrine

CAS: 24880-43-1

Natural alkaloid

Formula: C₁₇H₂₃NO₃

Purity: ≥ 90.0 % (HPLC)

Molecular weight: 289.37

Ref: 5G-26126

Mesembrine

Controlled Product

CAS: 24880-43-1

Applications An alkaloid used in preparing Channa, a drug of Southwest Africa. A serotonin-uptake inhibitor; occurs naturally as the (-)-form.
References Oh-Ishi, K., et al.: Chem. Pharm. Bull., 18, 299 (1970),

Formula: C₁₇H₂₃NO₃

Color and Shape: Light Yellow

Molecular weight: 289.37

Ref: TR-M338950

Mesembrine

Controlled Product

CAS: 24880-43-1

Mesembrine is a naturally occurring alkaloid that is found in plants of the genus Rauwolfia. It has been used as an anti-inflammatory and anti-tumor agent, and is also known to have hepatoprotective properties. Mesembrine has been shown to induce conformational changes in antibodies, which stimulates the production of antibodies that are specific for the new conformation. It also induces an antibody response against infectious diseases such as tuberculosis and malaria. The skeletal system of animals treated with mesembrine have exhibited a significant increase in locomotor activity, which may be attributed to its ability to inhibit bone resorption and stimulate bone formation. Mesembrine has been shown to have metabolic effects on mice, including lowering body weight and increasing liver weight. This is likely due to its ability to inhibit fatty acid synthesis by blocking the activity of acetyl-CoA carboxylase (ACC). It also has been shown to affect lipid metabolism by inhib

Formula: C₁₇H₂₃NO₃

Purity: Min. 95%

Molecular weight: 289.37 g/mol

Ref: 3D-FM25112

(-)-Mesembrine

CAS: 24880-43-1

Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).

Formula: C₁₇H₂₃NO₃

Color and Shape: Solid

Molecular weight: 289.37

Ref: TM-T28019