CAS 2488761-18-6

Benzamide, 2-[[2-[[4-(aminosulfonyl)phenyl]amino]-5-bromo-4-pyrimidinyl]amino]-6-fluoro-

Description:

Benzamide, 2-[[2-[[4-(aminosulfonyl)phenyl]amino]-5-bromo-4-pyrimidinyl]amino]-6-fluoro- is a synthetic organic compound characterized by its complex structure, which includes a benzamide core and multiple functional groups. The presence of a sulfonamide group contributes to its potential biological activity, particularly in medicinal chemistry. The compound features a bromine atom and a fluorine atom, which can influence its reactivity and interaction with biological targets. Its molecular structure suggests potential applications in pharmaceuticals, particularly as an inhibitor or modulator in various biochemical pathways. The compound's solubility, stability, and reactivity are influenced by the functional groups present, making it a candidate for further research in drug development. Additionally, the specific arrangement of atoms and substituents can affect its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME). Overall, this compound exemplifies the intricate design often found in drug-like molecules aimed at targeting specific biological processes.

Formula: C₁₇H₁₄BrFN₆O₃S

Synonyms:

• Benzamide, 2-[[2-[[4-(aminosulfonyl)phenyl]amino]-5-bromo-4-pyrimidinyl]amino]-6-fluoro-

TMX-3013

CAS: 2488761-18-6

TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.

Formula: C₁₇H₁₄BrFN₆O₃S

Color and Shape: Solid

Molecular weight: 481.3

Ref: TM-T201425